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Title: Bioinformatician/Microbiologist, Full Time–assigned to the Enteric Diseases Laboratory Branch (EDLB) within the Division of Foodborne, Waterborne, and Environmental Diseases (DFWED) at the US Centers for Disease Control and Prevention (CDC)
About: IHRC, Inc. provides scientific, information management and administrative program support to various Centers, Institutes and Offices of the Centers for Disease Control and Prevention (CDC) under several contracts.
MAJOR DUTIES AND RESPONSIBILITIES:
•Work very closely with EDLB Bioinformaticians to process raw sequence data produced by Sanger and NGS, to identify, characterize and annotate genes found in sequence data, perform evolutionary and phylogenetic studies of sequence data, identify unique regions of pathogen genomes for use as targets in molecular diagnostic assays, and design oligonucleotide primers/probes for use in sequencing projects and foodborne bacteria pathogen detection assays.
•Analyze genetic sequencing data utilizing new methodologies or existing techniques that have been properly revised and validated.
•Develop, evaluate, and validate bioinformatics tools to establish correlations between unique genetic markers (extracted from whole genome sequences) and the species/serotype of foodborne bacterial pathogens.
•Perform standard molecular biology techniques, including but not limited to, manual and automated nucleic acid extraction, Polymerase Chain Reaction (PCR), Sanger sequencing, and Next Generation Sequencing (NGS) to develop and validate schemes to rapidly identify and subtype bacterial pathogens from complex matrices.
•Evaluate novel approaches to address human and commensal bacterial DNA in disease state stool, including clutter mitigation.
•Assist with the establishment of procedures for Quality Assurance (QA) and Quality Control (QC) of sequence data analysis in the context of this project.
•Assist in implementation of the developed assays by training laboratorians from state, county and local public health laboratories.
•Prepare reports, charts, graphs, and presentations as required.
Minimum Qualifications and Technical Requirements:
•Must have successfully completed a full 4-years course of study in an accredited college or university leading to a bachelor’s and a higher degree (Master’s or Ph.D.) with at least 24 semester hours in mathematics, statistics, bioinformatics, or informatics and 24 semester hours molecular biology, microbiology, or genetics.
•Be proficient in the use of various whole genome sequence laboratory procedures.
•Be proficient in the analysis, assembly, and annotation of genomic data from a variety of sequencing platforms such as Illumina and PacBio.
•Have strong interpersonal skills since the work is to occur in a multidisciplinary team environment and extensive interaction with people across CDC and external partners is required.
•Have strong written and oral presentation skills.
•Be capable of developing and executing research tasks independently.
•REQUIRED experience with Illumina sequencing technology, molecular biology assay design, UNIX (BASH scripting) and cluster computing (SGE); experience with coding in PERL and/or PYTHON; experience with relational databases (i.e. MySQL, Microsoft SQL server), Microsoft Excel, Microsoft Word.
•DESIRABLE experience with Microsoft Access, SAS, experience with metagenomics databases such as Kraken and MetaPhlAn, prior work with bacterial genome sequencing and analysis.
•The candidate must possess excellent oral and written communication
Contact Person for Job Opportunity:
To apply for this position visit www.ihrc.com/careers . If already on the IHRC website, click on the job you are interested in and click on the apply button at the bottom of the page.
IHRC, Inc. is an equal opportunity and affirmative action employer. It is the policy of IHRC, Inc. to provide equal employment opportunities without regard to race, color, religion, sex, national origin, age, veteran or disability status and to take affirmative action in accordance with applicable laws and Executive Orders.