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Tag: Neuroscience

SPOTLIGHT ON JOBS: Pfizer Inc.

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Members of the Brandeis GPS Community may submit job postings from within their industries to advertise exclusively to our community. This is a great way to further connect and seek out opportunities as they come up. If you are interested in posting an opportunity, please complete the following form found here.

Where: Pfizer Inc: Cambridge, MA

Position: Several Positions available in Human Genetics and Computational Biomedicine

The advance of human genetics in recent years driven by the large scale human genome-sequencing and genome-wide association in multiple disease areas has brought the research community and pharmaceutical industry an unprecedented opportunity to utilize this information and technology to facilitate innovative drug discovery and development. Pfizer has now reached a key point at which human genetics is sufficiently mature to aid the drug discovery process in several important areas.

Inflammatory and autoimmune diseases and Neuroscience stand out as areas where genetic research has been successful, suggesting that increased emphasis and resource may yield ever more safe and efficacious precision medicines. A combination of genetic epidemiology and functional genomics will facilitate our ability to identify mechanisms, indications, patients and biomarkers, all of which would be guided by an evidence base in humans.

Opportunities also exist to integrate human genetics with other types of data measured in clinical research such as gene expression via RNAseq, protein measurements in peripheral blood, structural and functional brain imaging, and immune cell responses to treatment. This will enable holistic view of biomarker response. Carefully designed and implemented pharmacogenetic studies of drug responses in clinical trials could provide novel mechanistic learnings to support combination therapy or biomarkers for patient stratification.

Pfizer is looking for experts in human genetics with sound knowledge of applying human genetics and genomics as tools for target discovery/validation, biomarker/indication identification, patient stratification through genetic association analyses and functional biology studies.

 

Click here to view further details on this opportunity!

Any further questions on the position may be directed to Megan Harrigan at megan.harrigan@pfizer.com.

Interested candidates are asked to submit a resume/cv and cover letter through the Pfizer online portal here.

Please make sure to reference seeing this position through the Brandeis GPS job spotlight post.

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SPOTLIGHT ON JOBS: Merck (several positions)

spotlight-CHANGED-300x200SPOTLIGHT ON JOBS

Members of the Brandeis GPS Community may submit job postings from within their industries to advertise exclusively to our community. This is a great way to further connect and seek out opportunities as they come up. If you are interested in posting an opportunity, please complete the following form found here.

WhereMerck & Co. Inc, Kenilworth, NJ.

About: Merck & Co. Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career..

Positions:

Principal Scientist, Target & Pathway Biology – Cardiometabolics

We are seeking an experienced laboratory scientist with expertise in human genetics and cardiometabolic disease biology to join Target and Pathway Biology group within the department of Genetics & Pharmacogenomics (GpGx) at MRL Boston.  Our mission in GpGx is to leverage human genetics and cutting edge molecular biology technologies to identify and functionally validate novel targets and pathways for therapeutic intervention. The successful candidate will lead a team of biologists providing experimental validation of potential drug candidates.

Principal Scientist, Target & Pathway Biology – Immunology

We are seeking an experienced laboratory scientist with expertise in human genetics and immunological disease biology to join Target and Pathway Biology group within the department of Genetics & Pharmacogenomics (GpGx) at MRL Boston.  Our mission in GpGx is to leverage human genetics and cutting edge molecular biology technologies to identify and functionally validate novel targets and pathways for therapeutic intervention. The successful candidate will lead a team of biologists providing experimental validation of potential drug candidates.

Principal Scientist, Target & Pathway Biology – Neuroscience

We are seeking an experienced laboratory scientist with expertise in human genetics and neuroscience disease biology to join Target and Pathway Biology group within the department of Genetics & Pharmacogenomics (GpGx) at MRL Boston.  Our mission in GpGx is to leverage human genetics and cutting edge molecular biology technologies to identify and functionally validate novel targets and pathways for therapeutic intervention. The successful candidate will lead a team of biologists providing experimental validation of potential drug candidates.

Computational Biologist, Biologics, Genetics and Informatics IT (BGIx),

The Merck Biologics, Genetics and Informatics IT department (BGIx) works closely with the Genetics and Pharmacogenomics (GpGx) group in Merck Research Labs (MRL) to develop novel therapies grounded in human genetics, including the identification of new therapeutic targets and the development of clinical genomic biomarkers. The BGIx group seeks to significantly expand its team, by adding three bioinformatics and computational biology experts to support expanding research efforts in this area.
Specifically, we seek individuals to partner with GpGx and assist with:
1) analysis of large-scale human genome sequencing efforts for target discovery,
2) design and analysis of custom sequencing experiments to support target validation (single-cell sequencing, long-read technologies, multiplex screening approaches, etc.)
3) integration and analysis of data from diverse sources including microarray expression and genotyping, NGS-based experiments, flow cytometry, and clinical endpoints, and 4) management of genomic and genetic data from pre-clinical and clinical programs.

Interested candidates should apply using the careers website through the MSD Career Firm conducting the search for these positions

Make sure to reference seeing this position through the Brandeis GPS job spotlight post.

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