Adriane Otopalik

Grad Student

Volen Center for Complex Systems
Brandeis University,
Mailstop 013
415 South Street
Waltham MA 02454

Tel: (781) 736-3134
Fax: (781) 736-3142

B.A., Wellesley College, 2011

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Otopalik AG, Shin J, Beltz BS, Sandeman DC, Kolodny NH. (2012) Differential uptake of MRI contrast agents indicates charge-selective blood-brain interface in the crayfish. Cell & Tissue Research 349(2):493-503; PMID: 22526631

In the STG, we have characterized the effects of individual neurotransmitters and diffuse modulatory substances on cell and circuit function.  Yet, any single cell in the ganglion may express numerous receptors, allowing for simultaneous response to multiple extracellular substances and/or perturbations.  The cellular response to multiple modulators translates to a combinatorial change in membrane currents.  I am interested in exploring the degree to which multiple currents influence and/or compensate for each other in maintaining overall circuit function. Investigating this in the STG will expand our understanding of neural circuit function in the mammalian brain, where neurons are exposed to a variable cocktail of extracellular substances.