Dr. Timothy O’Leary

Post-Doctoral Researchermugshot

Volen Center for Complex Systems
Brandeis University,
Mailstop 013
415 South Street
Waltham MA 02454
USA

Tel: (781) 736-3134
Fax: (781) 736-3142

Education:
MMath Mathematics (Warwick 2002)
MRes Informatics (Edinburgh 2005)
PhD Neuroscience/biophysics (Edinburgh 2009)

O’Leary T, Marder E (2014) Mapping Neural Activation onto Behavior in an Entire Animal Science 344(6182)

O’Leary T, Williams AH, Franci A, Marder E (2014) Cell types, network homeostasis and pathological compensation from a biologically plausible ion channel expression model. Neuron 82(4) Link Perspective by Calabrese

Marder E, O’Leary T, Shruti S (2014) Neuromodulation of Circuits with Variable Parameters: Single Neurons and Small Circuits Reveal Principles of State-Dependent and Robust Neuromodulation. Annual Review of Neurosicence 37(1) Link

Williams AH, Calkins A, O’Leary T, Symonds R, Marder E, & Dickinson PS (2013) The Neuromuscular Transform of the Lobster Cardiac System Explains the Opposing Effects of a Neuromodulator on Muscle Output. The Journal of Neuroscience 33(42); PubMed link

Nowakowski TJ, Mysiak KS, O‘Leary T, Fotaki V, Pratt T, Price DJ (2013) Loss of functional Dicer in mouse radial glia cell-autonomously prolongs cortical neurogenesis Developmental Biology PubMed link

O’Leary T, Williams AH, Caplan JC, Marder E (2013) Correlations in ion channel expression emerge from homeostatic tuning rules. PNAS 110(28); PubMed link F1000 Recommended

Gutierrez GJ, O’Leary T, Marder E. (2013) Multiple mechanisms switch an electrically coupled, synaptically inhibited neuron between competing rhythmic oscillators. Neuron 77(5); PubMed link F1000 Recommended

Williams AH, O’Leary T*, Marder E (2013) Homeostatic Regulation of Neuronal Excitability. Scholarpedia 8(1):1656; Link

McMahon A, Barnett M, O’Leary T, Stoney P, Collins M, Papadia S, Choudhari J, Komiyama N, Grant S, Hardingham G, Wyllie DJ, Kind PC (2012) Activity-dependent alternative promoter usage and alternative splicing enable SynGAP isoforms to exert opposing effects on synaptic strength. Nature Communications 3(900); PubMed link

O’Leary T, Wyllie DJ. (2011) Neuronal Homeostasis: time for a change? The Journal of Physiology 589(20):4811-26; PubMed link

O’Leary T, van Rossum MC, Wyllie DJ (2010) Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization. The Journal of Physiology 588(1):157-70; PubMed link Perspective by D’Angelo

Clayton EL, Sue N, Smillie KJ, O’Leary T, Bache N, Cheung G, Cole AR, Wyllie DJ, Sutherland C, Robinson PJ, Cousin MA (2010) Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles. Nature Neuroscience 13(7):845-51; PubMed link

O’Leary T, Wyllie DJ (2009) Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits. Biochem Soc Trans. 37(6):1347-54; PubMed link

Otton HJ, Janssen A, O’Leary T, Chen PE, Wyllie DJ (2009) Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit. Eur J Pharmacol. 614(1-3):14-21; PubMed link

O’Leary T, Wyllie DJA (2008) The ups and downs of synaptic plasticity: influences on this particular ‘market’ The Journal of Physiology 586(24), 5839-5840

O’Leary T, Marder E (2014) One rule to grow them all? Activity-dependent regulation for robust neural circuit specification CoSyne

O’Leary T, Williams AH, Caplan JS, Marder E (2013) Correlations in ion channel expression emerge from homeostatic regulation mechanisms SfN

O’Leary T, Williams AH, Caplan JS, Marder E (2013) How conductance distributions are shaped by activity-dependent regulation rules, CNS in BMC Neuroscience 14 (Suppl 1)

O’Leary T, Marder E (2012) Neuronal homeostasis: inside the black box SfN

O’Leary T, Wyllie DJ (2011) Distributed control strategies for conductance regulation in dendrites Physoc

  • Intrinsic electrical properties of neurons (experimental)
  • Synaptic transmission and plasticity (experimental)
  • Computational modelling of excitable cells and neuronal networks
  • Systems biology of regulatory control
  • Data analysis and signal processing
  • Statistical modelling and inference

Current projects

  • Models of ion channel regulation in single cells and small circuits
  • Modelling robust neuromodulation
  • Analysis of biological feedback control and stability (with Alessio Franci)
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