Jonathan Caplan

Grad Student

Volen Center for Complex Systems
Brandeis University,
Mailstop 013
415 South Street
Waltham MA 02454
USA

 

To send me an email click here

Tel: (781) 736-3134
Fax: (781) 736-3142

Education:
B.A., Hampshire College

M.Ed. University of Massachusetts, Amherst

Background: I came to computational neuroscience after teaching high school science for several years.

Research Interests:
I am interested in creating biophysically realistic models of small networks. I search for models which accurately reflect the characteristics of identified pattern generating cells in the crab stomatogastric ganglion. I am interested in understanding how these networks can be robust in the face of changes such as temperature fluctuations.

Current Projects:

I am exploring temperature scaling in models of the STG pacemaker kernel in an attempt to understand the constraints on this scaling required to produce the phase maintenance recorded in vivo.

Publications:

Tang, Goeritz, Caplan, Taylor, Fisek and Marder. Precise temperature compensation of phase in a rhythmic motor pattern. PLoS Biol. 2010 Aug 31;8(8). pii: e1000469 PMCID: PMC2930868 doi: 10.1371/journal.pbio.1000469

Szabo, Caplan, Zoran 2010. Serotonin regulates electrical coupling via modulation of extrajunctional conductance: H-current. Brain Res. 2010 Aug 19;1349:21-31. PMID: 20599836 doi: 10.1016/j.brainres.2010.06.025

Kispersky*, Caplan* and Marder 2012. Increase in Sodium Conductance Decreases Firing Rate and Gain in Model Neurons. J Neurosci 8 August 2012, 32(32) 10995. doi: 10.1523/JNEUROSCI.2045-12.2012

O’Leary T, Williams AH, Caplan JS, Marder E. 2013. Correlations in ion channel expression emerge from homeostatic tuning rules. Proc Natl Acad Sci USA. 2013 July 9;110(28):E2645-54. doi: 10.1073/pnas.1309966110.