Volen Center for Complex Systems
415 South Street
Waltham MA 02454
Tel: (781) 736-3134
Fax: (781) 736-3142
B.A., Hampshire College
M.Ed. University of Massachusetts, Amherst
Background: I came to computational neuroscience after teaching high school science for several years.
I am interested in creating biophysically realistic models of small networks. I search for models which accurately reflect the characteristics of identified pattern generating cells in the crab stomatogastric ganglion. I am interested in understanding how these networks can be robust in the face of changes such as temperature fluctuations.
I am exploring temperature scaling in models of the STG pacemaker kernel in an attempt to understand the constraints on this scaling required to produce the phase maintenance recorded in vivo.
Tang, Goeritz, Caplan, Taylor, Fisek and Marder. Precise temperature compensation of phase in a rhythmic motor pattern. PLoS Biol. 2010 Aug 31;8(8). pii: e1000469 PMCID: PMC2930868 doi: 10.1371/journal.pbio.1000469
Szabo, Caplan, Zoran 2010. Serotonin regulates electrical coupling via modulation of extrajunctional conductance: H-current. Brain Res. 2010 Aug 19;1349:21-31. PMID: 20599836 doi: 10.1016/j.brainres.2010.06.025
Kispersky*, Caplan* and Marder 2012. Increase in Sodium Conductance Decreases Firing Rate and Gain in Model Neurons. J Neurosci 8 August 2012, 32(32) 10995. doi: 10.1523/JNEUROSCI.2045-12.2012
O’Leary T, Williams AH, Caplan JS, Marder E. 2013. Correlations in ion channel expression emerge from homeostatic tuning rules. Proc Natl Acad Sci USA. 2013 July 9;110(28):E2645-54. doi: 10.1073/pnas.1309966110.