Rosenstiel Award lectures on Mar 22 to honor Susan Lindquist

James Haber, Director of the Rosenstiel Center, writes:

The 46th annual Rosenstiel Award for Distinguished Work in Basic Medical Research was awarded last October to Susan Lindquist (MIT), one of the most inventive and influential life scientists of our generation.  Sue tragically passed away a few weeks thereafter; in her honor we have arranged a symposium to celebrate her lab’s great legacy.  The Award talks will be held in next Wednesday, March 22, in Gerstenzang 123 from 3:30 PM to 5:30 PM, followed by a reception open to all in the Shapiro Science Center atrium.  We hope you will all come to honor Sue Lindquist and to be edified by the excellent work carried out by her former colleagues.

Angelika Amon  (Massachusetts Institute of Technology)
“The Remarkable Scientific Life of Susan Lindquist”

Leah Cowen (University of Toronto)
“Harnessing Evolution to Thwart Microbial Drug Resistance and Treat Infectious Disease”

Daniel Jarosz (Stanford University)
“Remembering the Past: A New Form of Protein-Based Inheritance”

Sandro Santagata (Brigham and Women’s Hospital)
“Heat Shock Factor (HSF1): A Powerful Driver of Malignancy”

Susan Lindquist


From PhD to Life

By Craig W. Stropkay, (PhD ’13, Molecular and Cell Biology, Ren lab)

Reach for the stars, they said. You should definitely go get your PhD, you’d be great for it, they said. Well, I guess they did have a point. Pursuing my doctorate degree in Molecular Biology at Brandeis was definitely one of the most challenging things that I have ever had to do in my life. I could spend hours telling you about the long hours I spent trying to construct my dissertation or the countless nights that I had to wake up and drive into the lab from Medford just to “feed” my cells — but that’s not the point of this article. I want to talk about something that I wish was more openly discussed when I first started my journey towards pursuing a PhD. Something that I believe is important to anyone who is currently working their way towards earning their doctoral degree: a job.

Now I know what you may be thinking: why would I need to worry about a job when I know I will continue onto a postdoc and then a tenure-track academic post? Isn’t that what everyone does? That is precisely my point. Don’t get me wrong: there is absolutely nothing wrong with continuing a career in academia upon completion of your doctorate. It takes a lot of patience, skill, and dedication to remain in the field after you have literally spent years becoming an expert in everything dealing with Life Science. Maybe you’ve considered going that route, feeling that your choices are limited. Many people believe that apart from academia, their only “alternative” option is to go into industry and work in biotech or pharma.

Image from Naturejobs article

[Read more…]

8th Annual Pepose Award Lecture moved to Monday, March 13

Professor Frank Werblin, Professor Emeritus of Neuroscience at the University of California, Berkeley will receive the eighth annual Jay Pepose ’75 Award in Vision Sciences from Brandeis University on Monday, March 13 (date change due to impending snowstorm). The event will be held at 4 PM (room to be announced). At that time, Werblin will deliver a public lecture titled, “The Evolution of Retinal Science over the Last 50 Years.”

During his research, Professor Werblin identified a number of cellular correlates underlying visual information processing in the retina. He has authored many articles in peer-reviewed journals, and has contributed articles on retinal circuitry to the Handbook of Brain Microcircuits (Oxford University Press) and retinal processing in the Encyclopedia of the Eye (Elsevier). Werblin founded Visionize in 2013, a company dedicated to helping patients suffering from vision diseases that cannot be corrected with glasses or surgery.

The Pepose Award is funded by a $1 million endowment established in 2009 through a gift from Jay Pepose ’75, MA’75, P’08, P’17, and Susan K. Feigenbaum ’74, P’08, P’17, his wife. Pepose is the founder and medical director of the Pepose Vision Institute in St. Louis and a professor of clinical ophthalmology at Washington University. He founded and serves as board president of the Lifelong Vision Foundation, whose mission is to preserve lifelong vision for people in the St. Louis community, nationally and internationally through research, community programs and education programs. While a student at Brandeis, he worked closely with John Lisman, the Zalman Abraham Kekst Chair in Neuroscience and professor of biology at Brandeis.

“Exceptionally Helpful” Matthew Headrick Receives Award

Associate Professor of Physics Matthew Headrick was named by the American Physical Society as an Outstanding Referee for 2017. The award recognizes “scientists who have been exceptionally helpful in assessing manuscripts for publication in the APS journals”. Headrick, who works in string theory and related areas of theoretical physics, is one of 150 Outstanding Referees named this year, out of about 60,000 active referees for the APS journals. Headrick is not the only Brandeis physicist to have received this honor; Robert Meyer, now Emeritus Professor, was named an Outstanding Referee in 2011.

Headrick’s research is primarily focused on the intersection of quantum gravity, quantum field theory, and quantum information theory. He is specifically interested in information-theoretic aspects of holographic field theories (field theories that are dual to higher-dimensional gravitational theories), such as entanglement entropies and related quantities.

Leslie Griffith Receives SASTRA-Obaid Siddiqi Award

SASTRA award

Model depicts how the integration of light, ambient temperature, the circadian clock and homeostatic sleep drive sets the balance between daytime and nighttime sleep [Parisky, K.M., Agosto Rivera, J.L., Donelson, N.C., Kotecha, S. and Griffith, L.C. (2016) “Reorganization of sleep by temperature in Drosophila requires light, the homeostat and the circadian clock” Curr Biol 26:882-892]

Leslie C. Griffith, Nancy Lurie Marks Professor of Neuroscience and Director of the Volen National Center for Complex Systems, has received the SASTRA–Obaid Siddiqi Award for excellence in life sciences. The prize is given by the Shanmugha Arts, Science, Technology & Research Academy (SASTRA) University in Thanjavur, India. Siddiqi was a pioneering molecular biologist and founder of the Molecular Biology Unit of the Tata Institute for Fundamental Research.

Griffith’s interests range from the biochemistry of neuronal signal transduction, in particular the role of CaMKII in memory formation, to the hierarchical relationships between complex behaviors such as sleep and learning. She has contributed to our understanding of these issues using genetic approaches in Drosophila melanogaster and believes that model systems have an important place in pioneering the understanding of basic biological processes. Her lab has been active in developing tools that allow interrogation of molecular and cellular processes with temporal and spatial resolution in freely behaving animals to bridge the molecule-behavior gap.

Griffith received the award on February 28, 2017.

Dynamics of GreB-RNA polymerase interaction

Larry Tetone, Larry Friedman, and Melissa Osborne, and collaborators from the Gelles lab (Brandeis University) and the Landick lab (University of Wisconsin-Madison) used multi-wavelength single-molecule fluorescence methods to for the first time directly observe the dynamic binding and dissociation of an accessory protein with an RNAP during active transcript elongation.

Their findings are detailed in the recent paper “Dynamics of GreB-RNA polymerase interaction.” (PNAS, published online 1/30/2017).

Read more at The Little Engine Shop blog

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