Andrea Guerrero and Gina Turrigiano Receive 2020 Gilliam Fellowship

Gina Turrigiano & Andrea Guerrero

Andrea Guerrero (left) and Gina Turrigiano (right)

Andrea Guerrero, a Neuroscience PhD student working in the Turrigiano lab, a 2020 Gilliam Fellowships for Advanced Study recipient. The Gilliam Fellowship is awarded to the student and dissertation adviser, therefore Gina Turrigiano will also participate in this fellowship. Turrigiano said, “I am really pleased that Andrea was awarded this fellowship, which recognizes her potential to become a scientific leader.  I am also really excited at the opportunity to improve my mentoring skills that this terrific program provides to me as her PhD advisor.”

The purpose of the Gilliam Fellowship is to increase diversity among scientists who are preparing for leadership roles, particularly as college and university faculty members.  Fellows receive up to three years of support for dissertation research, typically in years three, four, and five of their PhD study. The Gilliam Fellowship is part of HHMI.

In response to receiving the award Guerrero said, “I am honored and excited to be selected as a 2020 HHMI Gilliam Fellowship recipient as it will aid my own advancement in an academic-track career and will importantly promote diversity and inclusion within the Brandeis science community.”

Andrea describes her research as follows:

“The human Shank3 gene is strongly associated with Autism Spectrum Disorder (ASD). Shank3 protein functions as a scaffold that plays a crucial role in synapse formation and maintenance. Prior work in our lab supports the idea that differential Shank3 phosphorylation alters its activity. Phosphomimetic and phosphodeficient mutants show dysfunction in the mechanisms that normally maintain brain circuitry homeostasis. In order to understand how Shank3 is able to do this, I will investigate how the phosphorylation state of Shank3 changes its synaptic localization, protein binding interactions, and cellular signaling pathways in vitro. Additionally, I will assess the effects of overexpression of Shank3 phosphorylation mutants on synaptic plasticity within the rodent primary visual cortex. My research project has the potential to uncover novel cellular pathways that can be targeted for ASD therapeutic development.”

 

 

Susan Lovett elected to the American Academy of Arts and Sciences

Susan LovettSusan Lovett, the Abraham S. and Gertrude Burg Professor of Microbiology, has been elected to the American Academy of Arts and Sciences. She was among the 276 outstanding individuals that were elected to the Academy in 2020 and announced on April 23. Brandeis University Professor, Anita Hill, joins Professor Lovett as a 2020 member of AAAS.

The Lovett lab studies the fundamental mechanisms by which cells preserve genetic information by the study of DNA damage repair and mutation avoidance in the model organism Escherichia coli. Additionally, they research how cell cycle events including DNA replication and chromosome segregation are coupled to cellular physiology and to the status of the chromosome.

Lovett joins other Brandeis science faculty members: Jeff Gelles, Gina Turrigiano, James Haber, Michael Rosbash, Eve Marder, David Derosier, Gregory Petsko, Stanley Deser, and Edgar Brown, Jr.

Founded in 1780, the Academy recognizes the outstanding achievements of individuals in academia, the arts, business, government, and public affairs.

Read more: BrandeisNow

Shinji Rho named 2020 Goldwater Scholar

Shinji Rho, Brandeis UndergraduateCongratulations to Shinji Rho who has been named a 2020 Goldwater Scholar.  The Goldwater Scholarship is a national scholarship designed to encourage outstanding students in their sophomore and junior year to pursue research careers in the fields of mathematics, the natural sciences, and engineering.

Shinji is currently a junior. Her project at Brandeis is on a transcriptional activator Gal4, which binds to upstream activating sequence (UAS) sites in the yeast genome to promote transcription. Previous studies have shown that dwell time of Gal4 on the UAS is significantly longer in purified systems than in cells. She is interested in finding the reason for this dwell time difference using single-molecule light microscopy. The findings of her project will provide a more realistic view of how transcription activation system behaves when nuclear proteins are present. 

Shinji plans to obtain a PhD degree in cancer biology, ultimately conducting research on developing more accurate and easily accessible breast cancer diagnosis methods.

Her mentor is Jeff Gelles, Aron and Imre Tauber Professor of Biochemistry and Molecular Pharmacology.

 

The Rogers Lab receives a prestigious international grant to study the origin of life

HFSP logoProfessor W. Benjamin Rogers in the Department of Physics has been awarded a 2020 Human Frontier Science Program (HFSP) collaborative Program Grant to create a self-propagating synthetic cell. The HFSP Program Grants aim to tackle big questions in the life sciences by supporting and bringing together researchers with different backgrounds from different countries. Professor Rogers’ team grant was one of 20 successful Program Grants that went through a year-long global selection process.

The project aims to build a stably-propagating cell from simple components. The cell will have a lipid membrane encapsulating DNA and transcription-translation machinery, and be able to grow and divide by internally synthesizing its own membrane material.

The project is significant because a stably propagating cell is a vital element of natural selection. Extant life on Earth is a consequence of natural selection acting upon earlier forms of life, shaping the lineages over time. Thus at some point early in life’s origins, a sustainably propagating cell must have emerged, allowing selective advantages to accumulate over successive generations. For daughter cells to have retained the attributes of their parent, both the genetic information and the cell contents must have been replicated with reasonable fidelity.  However, it is currently unclear how controlled cell division could have first emerged from relatively simple molecules. It is precisely this mystery that the team hopes to understand by attempting to recreate it in a test tube.

Professor Rogers’ grant is shared with Dr. Yutetsu Kuruma from Japan Agency for Marine-Earth Science and Technology and Professor Anna Wang from University of New South Wales in Australia.

Even Dankowicz is named 2019 Goldwater Scholar

Even Dankowicz, fly image

photo: Even Dankowicz

Even Dankowicz, a rising senior majoring in Biology, has been named a 2019 Goldwater Scholar. The Goldwater Scholarship is a national scholarship designed to encourage outstanding students in their sophomore and junior year to pursue research careers in the fields of mathematics, the natural sciences, and engineering.

He has always been particularly interested in animals (including insects), but it was a high school biology teacher that inspired Even to think more seriously about working with insects. “Insects and other arthropods seemed especially worth studying because they are disproportionately diverse and abundant, making up ~95% of the species I found in my yard. Up close, they are also often exceptionally beautiful.” The image above is one of his favorites – it is a wasp-like flower fly from his yard in Illinois.

After his freshman year at Brandeis, Even spent the summer at the Smithsonian revising the taxonomy of a tropical Asian Mydas-fly genus, discovering six new species. Last summer he worked at Harvard on a gene-sequence-based evolutionary tree of a tropical Asian butterfly genus. He has continued to be involved with both of these projects/research groups, and is currently back at the Smithsonian looking at the comparative morphology of fly pupae.

Along with Colleen Hitchcock, Assistant Professor of Ecology, Even worked on local biodiversity-focused citizen science, which has shown him the potential value of this data and motivated him to curate insect observations on iNaturalist and BugGuide, two citizen science websites. Even (with Chris Cohen from East Carolina University) recently contributed an article to Fly Times titled “Diptera and iNaturalist: A case study from Asiloidea”. The article provides a detailed description of iNaturalist. Dankowicz and Cohen used this platform extensively for their studies in Diptera.

In the future, Even says that he thinks he’d like to keep working with insects, “either to understand their evolution or another aspect of their biology.” This spring, Even took an class on evolutionary developmental biology (evo-devo) with Assistant Professor Maria de Boef Miara, which has been useful in his current project at the Smithsonian. Additionally, he is starting to work on applications for graduate school next year.

Sadelin & Campana Receive 2019 Gabbay Award on October 2

2019 Gabbay Award winners

Michel Sadelain, the director of the Center for Cell Engineering at the Memorial Sloan Kettering Cancer Center (MSKCC), and Dario Campana, a professor of pediatrics at the Yong Loo Lin School of Medicine at the National University of Singapore (NUS) will receive the 2019 Jacob and Louise Gabbay Award in Biotechnology and Medicine on Wednesday, October 2, 2019 at 4:00 PM at Shapiro Campus Center Theater. Michel Sadelin and Dario Campana will deliver a talk at that time.

Both scientists receive the Gabbay Award this year for their research into CAR T-cell therapy that has resulted in breakthrough cancer treatments.

The Gabbay Award was created in 1998 by the Jacob and Louise Gabbay Foundation in order to recognize scientists working in academia, medicine or industry for their outstanding achievements developing scientific content and significant results in the biomedical sciences.

Read more at BrandeisNow.

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