SPROUT and I-Corps Applications are Open

Sprout logoThe Brandeis Innovation SPROUT and I-Corps programs offer support for bench and non-bench research. Both programs offer funding in different amounts, mentorship, training and help in further exploring the commercial potential of inventions. SPROUT supports bench research, while I-Corps emphasizes training for both bench and non-bench researchers in developing the commercial potential of discoveries, with small grants and extensive training programs. You can apply to one or both programs.

  • If you have a technology / solution that you have started developing and you would like to get funding for it via SPROUT and/or I-Corps, then please complete this form
  • If you do not already have a technology, then you can complete this form to qualify for the I-Corps training program and be matched with a team

Icorps logo

SPROUT teams will get the chance to qualify for up to $30,000 in funding. The I-Corps program provides entrepreneurial training and covers the core of commercializing a technology or building a startup. It comes with an NSF $750 travel and training stipend and an NSF I-Corps certificate/digital badge.

Apply by February 25, 2020 at 11:59PM

Cooling Mosquitoes’ Drive for Human Blood

Drawing from Smithsonian Magazine depicting mmosquitoes and thermonter

Anopheles gambiae mosquitoes use a receptor called IR21a to navigate toward warmth, a cue that signals they’re near food (Crystal Zhu, Garrity Lab, Brandeis University).

In a recent Science paper, the Garrity lab reported that they have found an important step in how mosquitoes sense human warmth. Once found, human blood becomes a food source for the insects’ eggs. Unfortunately,  mosquito bites have, over the centuries, spread disease and misery among humans.

The lab genetically modified mosquitoes to stop expressing a molecular thermostat called IR21a in their antennae. This reduced the insects’ ability to find the heat generated by humans. The hope is that this discovery will help remove the mosquitoes temperature sensors so they don’t spread disease. This discovery has also been summarized in the Smithsonian Magazine.

Paper: Mosquito heat seeking is driven by an ancestral cooling receptor. Chloe Greppi, Willem J. Laursen, Gonzalo Budelli, Elaine C. Chang, Abigail M. Daniels, Lena van Giesen, Andrea L. Smidler, Flaminia Catteruccia, Paul A. Garrity. Science  07 Feb 2020: Vol. 367, Issue 6478, pp. 681-684.

 

 

Goode, Gelles and Kondev labs synergize in discovery of a new synergistic actin depolymerization mechanism

Shashank Shekhar, Jane Kondev, Jeff Gelles and Bruce Goode

Shashank Shekhar, Jane Kondev, Jeff Gelles and Bruce Goode

All animal and plant cells contain a highly elaborate system of filamentous protein polymers called the actin cytoskeleton, a scaffold that can be rapidly transformed to alter a cell’s shape and function. A critical step in reconfiguring this scaffold is the rapid disassembly (or turnover) of the actin filaments. But how is this achieved? It has long been known that the protein Cofilin plays a central role in this process, but it has been unclear how Cofilin achieves this feat. Cofilin can sever actin filaments into smaller fragments to promote their disassembly, but whether it also catalyzes subunit dissociation from filament ends has remained uncertain and controversial. Until now, this problem has been difficult to address because of limitations in directly observing Cofilin’s biochemical effects at filament ends. However, a new study published in Nature Communications led by postdoctoral associate Dr. Shashank Shekhar, jointly mentored by Bruce Goode, Jeff Gelles and Jane Kondev, uses microfluidics-assisted single molecule TIRF imaging to tackle the problem.

The new study shows that Cofilin and one other protein (Srv2/CAP) intimately collaborate at one end of the actin filament to accelerate subunit dissociation by over 300-fold! These are the fastest rates of actin depolymerization ever observed. Further, these results establish a new paradigm in which a protein that decorates filament sides (Cofilin) works in concert with a protein that binds to filament ends (Srv2/CAP) to produce an activity that is orders of magnitude stronger than the that of either protein alone.

Video of cofilin and Srv2/CAP collaborating

The work was funded by National Institutes of Health, National Science Foundation MRSEC and Simons Foundation grant.

Alumni and Student Researchers Wow Crowd at 2019 SciFest

With a new alumni symposium in the morning and a poster session filling three floors of the Science Center atrium in the afternoon, this year’s SciFest IX set a new standard for Brandeis Science’s annual celebration of undergraduate research.


Photos: Heratch Ekmekjian

Since 2011, a poster session featuring the results from ongoing projects belonging to undergraduates doing science research has been the high point of summer in the Division of Science at Brandeis. This year, for the first time, we invited Brandeis alumni scientists to speak in a morning symposium entitled “A Celebration of Brandeis’ Undergraduate Science Education”, including:

Students and faculty in the audience were treated to a history of Brandeis and reflections on many of the Brandeis professors and courses that set them on their career path and whose influence persists to the present in how they approach their science, and on lessons they learned that continue to guide their work.

After lunch in the campus center, the crowd climbed up to the Shapiro Science Center for the poster session. 123 students presented 117 posters on topics from high-energy physics to biomaterials and from quantum chemistry to fruit fly behavior. As President Ron Liebowitz noted in an email to the Science community after the event:

The energy in Shapiro during the poster session was electric.  The students’ confidence and excitement over sharing their research can only give us great optimism about the future: they are “all in” when it comes to doing basic research, but also seeing how such research can be applied in the name of helping others.

Many of the posters can be found in the hallway in Gerstenzang – look for them when classes start again in a few weeks!

SciFest IX by the numbers

  • 117 posters
  • 123 student presenters (out of approx. 210 summer student researchers)
    • 105 Brandeis students
      • 99 presenting research done on campus
      • 6 presenting work done over the summer off-campus
    • 18 visiting students
  • 45 Brandeis faculty advisors from 7 departments
    • Biochemistry (7)
    • Biology (18)
    • Chemistry (8)
    • Computer Science (1)
    • Physics (6)
    • Psychology (5)
    • Sociology (1)

Even Dankowicz is named 2019 Goldwater Scholar

Even Dankowicz, fly image

photo: Even Dankowicz

Even Dankowicz, a rising senior majoring in Biology, has been named a 2019 Goldwater Scholar. The Goldwater Scholarship is a national scholarship designed to encourage outstanding students in their sophomore and junior year to pursue research careers in the fields of mathematics, the natural sciences, and engineering.

He has always been particularly interested in animals (including insects), but it was a high school biology teacher that inspired Even to think more seriously about working with insects. “Insects and other arthropods seemed especially worth studying because they are disproportionately diverse and abundant, making up ~95% of the species I found in my yard. Up close, they are also often exceptionally beautiful.” The image above is one of his favorites – it is a wasp-like flower fly from his yard in Illinois.

After his freshman year at Brandeis, Even spent the summer at the Smithsonian revising the taxonomy of a tropical Asian Mydas-fly genus, discovering six new species. Last summer he worked at Harvard on a gene-sequence-based evolutionary tree of a tropical Asian butterfly genus. He has continued to be involved with both of these projects/research groups, and is currently back at the Smithsonian looking at the comparative morphology of fly pupae.

Along with Colleen Hitchcock, Assistant Professor of Ecology, Even worked on local biodiversity-focused citizen science, which has shown him the potential value of this data and motivated him to curate insect observations on iNaturalist and BugGuide, two citizen science websites. Even (with Chris Cohen from East Carolina University) recently contributed an article to Fly Times titled “Diptera and iNaturalist: A case study from Asiloidea”. The article provides a detailed description of iNaturalist. Dankowicz and Cohen used this platform extensively for their studies in Diptera.

In the future, Even says that he thinks he’d like to keep working with insects, “either to understand their evolution or another aspect of their biology.” This spring, Even took an class on evolutionary developmental biology (evo-devo) with Assistant Professor Maria de Boef Miara, which has been useful in his current project at the Smithsonian. Additionally, he is starting to work on applications for graduate school next year.

NeuroSeq and cell diversity in the nervous system

The central nervous system has the most cellular diversity of any organ in the body, but how does this diversity arise?

While the presumption is that genetic programs specify each neuron type, our understanding of these programs is in its infancy. To begin uncovering the underlying design principles of neuronal architecture in the brain, scientists from the Nelson Lab at Brandeis University and the HHMI Janelia Research Campus jointly formed the NeuroSeq project to profile genetic programs in a monumental number of neurons throughout the nervous system. Selected neurons were from transgenic animals to facilitate access among the scientific community for future functional studies. While single cell sequencing is the most popular method for transcriptome profiling, its technical limitations only provide a shallow view of molecular profiles. To go deeper, the NeuroSeq program assessed transcription in pools of nearly 200 genetically identified mouse cell types. NeuroSeq captured 80% of single gene copies and could even assess splice isoforms.

What did the NeuroSeq effort find?

Interestingly, two unique classes of genes lie at the heart of adult neuronal identity. Homeobox transcription factors and long genes explain a great deal of the neuronal diversity in the central nervous system. This extends the role of homeobox genes well beyond development and into neuronal identity maintenance. It also highlights long genes as an important class of neuronal identity effectors. Long genes are long due to insertion of foreign elements, and they come with costs, namely increased energy consumption and risk of mutations. These costs seem to be overcome by the benefits of neuronal diversification. We are excited to spotlight the NeuroSeq project in providing a unique resource for future discoveries concerning neuronal diversity and function.

The data resource is available at neuroseq.janelia.org, and the findings are described in a recent paper in eLife. Brandeis-affiliated authors on the paper include Professor Sacha Nelson, former postdoc Ken Sugino PhD ’05 (now at HHMI Janelia), current postdoc Erin Clark, and former research scientist Yasuyuki Shima.

Genome illustration

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