HMS Professor Steven Harrison to Receive 48th Rosenstiel Award

Prof. Stephen C. Harrison will receive the 48th Rosenstiel Award for Distinguished Work in Basic Medical Research on March 25, 2019. He is being honored for his studies of protein structure using X-ray crystallography.  His work has ranged from the landmark elucidation of the structure of viruses, to understanding the recognition of DNA sequences by transcription factors, to the regulation of protein kinases implicated in cancer.

Harrison is the Giovanni Armenise-Harvard Professor of Basic Medical Sciences and Director of the Center for Molecular and Cellular Dynamics at the Harvard Medical School.  He is also Head of the Laboratory of Molecular Medicine at Boston Children’s Hospital and an Investigator of the Howard Hughes Medical Institute.   He has been elected a member of the US National Academy of Sciences, the American Academy of Arts and Sciences,  the American Philosophical Society; he is a foreign member of the Royal Society and the European Molecular Biology Organization.

Dr. Harrison’s initial studies of virus structure provided an understanding of how viruses invade cells and how virus particles are assembled.  He has extended his work to reveal the structures of many viruses, including influenza, HIV, ebola and dengue.  Knowledge of these structures is guiding the development of new vaccines against these viruses.  Moreover, the methodology that he and his colleagues developed to visualize virus structure has made it possible to learn about the molecular architecture of other very large assemblies of proteins.

Harrison’s lab has also revealed the ways that proteins recognize specific DNA sequences to regulate gene expression.  More recently his lab has been exploring the complex structure of the many proteins that are assembled in the kinetochore, which anchors the centromeres of chromosomes to microtubules, to permit their proper segregation in mitosis.

“Steve Harrison has done much more than giving us astonishing pictures of proteins at the atomic level; he has used this structural information to show us how these proteins perform their precise functions,” said James E. Haber, Director of the Rosenstiel Center for Basic Medical Sciences.

The Rosenstiel Award has had a distinguished record of identifying and honoring pioneering scientists who subsequently have been honored with the Lasker and Nobel Prizes. Awards are given to scientists for recent discoveries of particular originality and importance to basic medical research.

View full list of awardees.

 

 

Spencer Bloch to speak at 2018 Eisenbud Lectures

Eisenbud 2018 Poster

The 2018 Eisenbud Lectures in Mathematics and Physics will be held from November 13-15 at Brandeis University. This years speaker is Spencer Bloch, Professor of Mathematics at the Yau Mathematical Sciences Center at Tsinghua University, and Emeritus Professor of Mathematics at the University of Chicago.

Professor Bloch is a mathematician whose work has influenced many subjects including number theory, algebraic geometry and mathematical physics. The following lectures will be informative and entertaining:

  • Tuesday, November 13 at 4pm: “Multiple Zeta Values and Mixed Tate Motives over ℤ”  (intended for a general audience) Location: Abelson 131.
  • Wednesday, November 14 at 4pm: “Motivic Γ-functions” (colloquium style lecture). Location: Brown 316.
  • Thursday, November 15 at 4pm, “Relative Completions,” Location: Goldsmith 317.

Refreshments will be served 15 minutes before each talk. There will be a reception in Abelson 333 following Tuesday’s talk.

The Eisenbud Lectures are the result of a generous donation by Leonard and Ruth-Jean Eisenbud intended for a yearly set of lectures by an eminent physicist or mathematician working close to the interface of the two subjects.

HSSP undergraduate receives Critical Language Scholarship

CLS logoRegina Tham’20 has been awarded a Critical Language Scholarship. She is among the approximately 200 Brandeis students and recent alumni to receive fellowships and scholarships this year. A pre-health student majoring in Health: Science, Society, and Policy, Regina also works in the Leslie Griffith lab and is a Teaching Assistant for General Chemistry Lab.  Regina will be using her scholarship to study Mandarin Chinese in an intensive language program this summer.

 

 

 

Brandeisians Receive 2018 NSF Graduate Research Fellowships

NSF Graduate Research FellowshipFive Brandeisians (past and present) have received NSF Graduate Research Fellowships for 2018. Also, one current graduate student received an honorable mention.

This program recognizes and supports outstanding graduate students in NSF-supported STEM disciplines who are pursuing research-based advanced degrees at U.S. institutions. In 2018, the National Science Foundation (NSF) received over 12,000 applications, and made 2,000 award offers. This fellowship provides three years of financial support within a five-year fellowship period ($34,000 annual stipend and $12,000 cost-of-education allowance to the graduate institution).

Alyssa Garcia, a Brandeis Physics graduate student, received a fellowship. Marcelle Soares-Santos, Assistant Professor of Physics, is Alyssa’s advisor. Marcelle said “Alyssa will work on obtaining a sample of neutron star collisions with the goal of using them as standard sirens to determine the rate of expansion of the Universe.  This is very timely after the discovery of the groundbreaking neutron star collision GW170817 as the gravitational wave detectors are now being upgraded and when they come back later this year, they are expected to yield almost 10 times more detection’s per year. That wealth of data, is a very exciting prospect for a student starting their PhD career!”

Christopher Konow, a Ph.D. candidate in Chemistry, received an honorable mention. He works in the Irving Epstein lab analyzing the Turing Pattern formation in Growing Domains using the CDIMA (chlorine dioxide-iodine-malonic acid) chemical reaction.  For the NSF GRF, he proposed developing a novel self-oscillating hydrogel that could have uses in drug delivery.  He plans to start this project in late summer/early fall of 2018.

The Brandeis undergraduate alumni receiving 2018 NSF GR fellowships are:

  • Caroline Cappello graduated in 2011 with a bachelor’s degree in Environmental Studies and Theater Arts. She is a Ph.D. student in the Department of Biology at the University of Washington.
  • Emma Chad-Friedman received a BA in Psychology and Anthropology in 2014 and is in the PhD. Psychology program at the University of Maryland at College Park.
  • Jung Park also graduated in 2014 with a degree in Neuroscience and Psychology. He is currently a Ph.D. student in Neurobiology and Behavior at Columbia University.
  • Stanislav Popov received his B.S. degree in Mathematics and Chemistry only 2 years ago (2016). While at Brandeis, Stanislav worked in Isaac Krauss’ lab. He is pursuing a Ph.D. in Chemistry at UCLA.

Neuroscience Faculty Members Named AAAS Fellows

Leslie Griffith & Gina Turrigiano-2017 AAAS Fellows

Leslie Griffith (left) and Gina Turrigiano (right)

Leslie Griffith and Gina Turrigiano have been named American Association for the Advancement of Science (AAAS) Fellows for 2017. This is in recognition of their contributions and scientific leadership in the field of Neuroscience.

Leslie Griffith, Nancy Lurie Marks Professor of Neuroscience and Director of the Volen Center for Complex Systems, studies sleep and memory using Drosophila melanogaster.

Gina Turrigiano is the Joseph Levitan Professor of Vision Science. Her lab studies the mechanisms of homeostatic synaptic plasticity and their effects in developing and functioning cortex.

Vice Provost for Research Edward Hackett is also a 2017 AAAS Fellow in the Section on History and Philosophy in Science.

Griffith, Turrigiano, Hackett and the other Fellows for 2017 will be recognized on Saturday, Feb. 17, 2018 at the 2018 AAAS Annual Meeting in Austin, Texas.

Read more at BrandeisNow.

Titia de Lange to receive 47th Rosenstiel Award

Professor Titia de Lange

The 47th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research has been awarded to Professor Titia de Lange of Rockefeller University for her studies on the protection of chromosome ends (telomeres) from degradation and rearrangement. Professor de Lange will receive the award on April 12, 2018 at Brandeis University where de Lange will present a public lecture.

Dr. de Lange’s laboratory identified and characterized the roles of proteins that compose the shelterin complex, which binds specifically to the special telomeric DNA sequences and maintains the stability of these ends.  Dr. de Lange’s work has shown that the shelterin complex and the unusual telomere-loop structure of telomere DNA prevent these ends from being detected as broken chromosome ends and thus protect telomeres from being degraded and rearranged as are the ends at chromosome breaks.  De Lange’s work has further shown that disabling different components of shelterin triggers different cellular alarms designed to detect broken and degraded DNA ends and leads to lethal chromosome rearrangements such as the fusion of chromosomes.  In addition, her lab has gained critical insights into the mechanisms of cellular response to the presence of DNA damage and recently has defined processes that lead to massive chromosome rearrangements (chromothripsis) associated with many human cancers.

She is the Leon Hess Professor and director of the Anderson Center for Cancer Research at Rockefeller University, as well as an American Cancer Society Research Professor.  Her honors include: the Life Sciences Breakthrough Prize, the Rosalind E. Franklin Award from the National Cancer Institute, the Vilcek Prize in Biomedical Sciences, election as a foreign member of the US National Academy of Sciences and as Fellow of the American Academy of Arts and Sciences.

The Rosenstiel Award has had a distinguished record of identifying and honoring pioneering scientists who subsequently have been honored with the Lasker and Nobel Prizes.  Professor de Lange joins a long list of past awardees.

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