Mediating the early response to acute hypoxia

Neurons in the brain require a continuous supply of oxygen for normal activity. If the level of oxygen in the brain decreases—for example when a blood vessel becomes blocked—neurons begin to die, and permanent brain damage can result. A shortage of oxygen first causes sodium ion channels within the surface membrane of the neurons to open. Sodium ions then flow into the cells through these open channels to trigger a cascade of events inside the cells that ultimately results in their death.

In “SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons” (Elife), Plant et al. now reveal how oxygen deficiency, otherwise known as hypoxia, rapidly increases the flow of sodium ions into brain cells. By inducing hypoxia in neurons from rat brain, Plant et al. show that a lack of oxygen causes SUMOylation, a process whereby a series of enzymes work together to attach a Small Ubiquitin-like Modifier (or SUMO) protein, of specific sodium ion channels in under a minute. The channels linked to the SUMO protein, a subtype called Nav1.2, open more readily than unmodified channels, allowing more sodium ions to enter the neurons.

Plant et al. study granule cells of the cerebellum, the most numerous type of neuron in the human brain. Further investigation is required to determine if SUMOylation of Nav1.2 channels underlies the response of other neurons to hypoxia as well. It also remains to be discovered whether molecules that block the SUMOylation of Nav1.2 channels, or that prevent the flow of sodium ions through these channels, could reduce the number of brain cells that die in low-oxygen conditions such as stroke.

doi: 10.7554/eLife.20054.
SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons
Leigh D Plant, Jeremy D Marks, Steve AN Goldstein
eLife 2016;5:e20054

2 New Faculty Members Join Biochemistry

Tijana Ivanovic and Maria-Eirini Pandelia have joined the Biochemistry department. Both of the new faculty members will begin at Brandeis in January 2016.

tijana_photoTijana Ivanovic, is currently a postdoc at Harvard Medical School.  Stephen C. Harrison is her advisor. She received her PhD in Virology from HMS and her BS in Microbiology and Molecular Genetics from UCLA.

Her research focuses on uncovering fundamental molecular mechanisms of virus translocation across biological membranes, in the distinct contexts of enveloped-virus membrane fusion and nonenveloped-virus membrane penetration.  She applies and develops advanced biophysical and biochemical approaches and combines them with those of virology, molecular biology and cell biology.

Dr. Ivanovic received a grant from the L’Oréal USA For Women in Science fellowship program in 2011.

pandeliaMaria-Eirini Pandelia‘s ‘scientific journey’ started from Greece, where she received her undergraduate degree in Physics from the University of Patras and master of sciences degree in applied Mathematics and Physics from the National Technical University of Athens. She carried out her graduate studies in Germany at the Max-Planck Institute (MPI) of Chemical Energy Conversion (formerly known as MPI for Bioinorganic Chemistry) and received her doctoral degree from the Technical University of Berlin. This was followed by 3 years as a postdoc at PennState University in the Bollinger/Krebs laboratory.

Her research lies in the interface of Chemistry, Biology and Physics with particular focus on the study of metalloenzymes. Her work encompasses the combination of spectroscopic and biophysical techniques together with structural biology and phylogenetics to address the modus operandi of metalloproteins and bioinorganic complexes. Her main expertise is in Mössbauer and EPR spectroscopies coupled to time-resolved kinetics (optical, FTIR) and redox potentiometry. She is interested in understanding how diverse enzymes carry out their bio-transformations and how reaction selectivity in homologous proteins is achieved.

Maria-Eirini’s work at Brandeis will be centered on delineating the mechanisms according to which metalloproteins involved in processes essential for life perform the activation of small (or larger) molecules, how the specific identity of the metals in the active sites allows their chemical diversion and selectivity and what the functional role of iron-sulfur clusters in proteins involved in DNA synthesis and repair is.






SPROUT grant opportunity for 2015 announced

From the Brandeis Office of Technology Licensing:

The Brandeis Virtual Incubator invites members of the Brandeis Community (faculty, staff and students) to submit an application for the SPROUT Program. These Awards are intended to stimulate entrepreneurship on campus and help researchers launch their ideas and inventions from the lab to the marketplace.The SPROUT Program will provide pilot funding for innovative scientific projects within the Division of Science that require bench research, lab space, and/or lab equipment.

We will be awarding $50,000 to be shared among the most promising proposals.
Come get your questions answered at one of our upcoming information sessions.
Info Sessions: 
Thursday, February 26,  11:00 a.m.-12:00 p.m. (Volen, room 201)
Monday, March 2,  2:00 p.m.-3:00 p.m.   (Shapiro Science Center, 1st Floor Library, room 1-03)
Deadlines: Preliminary Proposals are due by Friday, March 6th
Please note, the introduction of the new SPARK Program geared towards innovative non-bench projects that have impact. An additional email will be sent detailing this program.
For more information on each program go to our website or contact the OTL program leaders,  Melissa Blackman for SPROUT and  Anu Ahuja  for SPARK.

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