Amyloid fibrils are associated with Alzheimer’s disease. In a recent study published in J. Mol. Biol., Nikolaus Grigorieff and coworkers used electron cyro-microscopy to study these structures and show that these fibrils coexisting in solution can be extremely polymorphic.
Structural diversity of amyloid fibrils
December 6, 2008 By
Multiple loops in DNA-protein binding complexes
November 11, 2008 By
Recent results from the Gelles lab published in PLoS Biology show that lac repressor bound to DNA can form different loop structures and that there are rapid transitions between the structures.
Gabbay Award
November 7, 2008 By
On Monday, Nov 10, Prof. Alfred Goldberg from Harvard Medical School will be on campus to receive the 2008 Jacob Heskel Gabbay Award and to deliver a lecture on the topic “Functions of the proteasome from protein degradation and immune surveillance to cancer therapy”
For more information, see the online exhibit at brandeis.libguides.com
IMPDH and retinal degeneration
November 5, 2008 By
Recent work from the Hedstrom Lab suggests an explanation for how mutations in this enzyme involved in nucleotide biosynthesis can lead to retinal degeneration and hereditary blindness. It seems it has to do with binding mRNA. Read more at:
Rotation Talks
October 31, 2008 By
Rotation talks by Biochemistry and Biophysics first-years today, Fri, 10/31/08 in Gerstanzang 121, 11:30am.
There will be pizza.
