James Collins to receive the 2017 Gabbay Award on Oct. 18

James Collins

On Wednesday, October 18, 2017, the 2017 Jacob and Louise Gabbay Award in Biotechnology and Medicine will be given to James J. Collins from MIT. Professor Collins will be delivering his lecture entitled Synthetic Biology: Life Redesigned at 4:00pm at Brandeis in Gerstenzang 121.

Professor Collins is receiving the award “for his inventive work in synthetic biology that created a new area of research, enabling multiple biomedical applications and launching a new sector of the biotechnology industry”. He is the Termeer Professor of Medical Engineering and Science and Professor of Biological Engineering at MIT, also Core Founding Faculty at the Wyss Institute (Harvard University) and an Institute Member of the Broad Institute.

The Gabbay Award was created in 1998 by the Jacob and Louise Gabbay Foundation in order to recognize scientists working in academia, medicine or industry for their outstanding achievements developing scientific content and significant results in the biomedical sciences.

 

Jeffery Kelly to receive the 2016 Jacob and Louise Gabbay Award

jefferywkelly

Jeffery W. Kelly

Jeffery W. Kelly, the Lita Annenberg Hazen Professor of Chemistry, and Chairman of the Department of Molecular and Experimental Medicine at the Scripps Research Institute, has been selected to receive the 2016 Jacob and Louise Gabbay Award in Biotechnology and Medicine “in recognition of his profound and paradigm-shifting contributions to our understanding of protein folding mechanisms and protein misfolding diseases”.

The award, administered by the Rosenstiel Center at Brandeis, consists of a $15,000 cash prize and a medallion. Dr. Kelly will deliver the award lecture on “The Chemistry and Biology of Adapting Proteostasis for Disease Intervention” in the Shapiro Campus Center Theater at 4:00PM, on Thursday, September 29, 2016.

The Kelly Group focuses their research on understanding the principles of protein folding and comprehending the basis for misfolding diseases. They strive to develop novel therapeutic strategies using chemistry, biophysical and cell biology approaches.

 

Bisphenol A researchers win Gabbay Award

Bisphenol A (BPA) has been used in the synthesis of polycarbonate plastics over the years. BPA is also a powerful estrogen analog. Three researchers, Patricia Hunt (Washington State Univ.), Ana Soto (Tufts) and Carlos Sonnenschein (Tufts), will today be awarded the 2012 Jacob Heskel Gabbay Award for their work identifying the cellular and developmental effects of BPA exposure. The three will lecture today, Oct. 22, at 3:30 pm in Rapaporte Treasure Hall, Goldfarb Library.

see also story at BrandeisNOW

James P. Allison to deliver Gabbay Award Lecture

James Allison, PhD  from the Memorial Sloan-Kettering Cancer Center will receive the 2011 Jacob Heskel Gabbay Award in Biotechnology and Medicine “for his development of strategies for the treatment of autoimmune diseases and for immunotherapy of cancer”. The award, administered by the Rosenstiel Center at Brandeis, consists of a $15,000 cash prize and a medallion. Dr. Allison will deliver the award lecture on Mobilizing the immune system to treat cancer: Immune checkpoint blockade, on Monday, Nov 14, 2011 at 3:30 pm in Gerstenzang 121.

Allison and his lab are interested in the mechanisms that regulate T cell responses and using that understanding to improve clinical outcomes in areas ranging from autoimmunity, to allergy to vaccination to  tumor therapy.

Breast cancer drug inventor to receive 2010 Gabbay Award

Angela Brodie, Ph.D. from the University of Maryland Greenebaum Cancer Center will receive the 2010 Jacob Heskel Gabbay Award in Biotechnology and Medicine. The award, administered by the Rosenstiel Center at Brandeis, consists of a $15,000 cash prize and a medallion. Dr. Brodie will deliver the award lecture, Aromatase Inhibitors and Breast Cancer: Concept to Clinic, on October 12, 2010 at 4:00 pm in Gerstenzang 121.

Dr. Brodie pioneered the development of aromatase inhibitors, a new class of drugs widely used today to treat breast cancer. Aromatase is the key enzyme in estrogen biosynthesis. Aromatase inhibitors reduce the level of estrogen produced by the body that fuels the growth of breast cancer cells. Although tamoxifen is effective in treating breast cancer, the antiestrogen is a partial agonist as well as an antagonist and may not be optimally effective against breast cancer. By using a different approach, Dr. Brodie reasoned that compounds that inhibit the production of estrogen without having significant estrogenic activity themselves might be more effective in treating breast cancer.
Dr. Brodie began developing aromatase inhibitors with her husband Harry Brodie in the early 1970s. She showed that the most potent inhibitor identified, 4-hydroxyandrostenedione (4-OHA) was effective in suppressing estrogen levels and causing regression of mammary tumors in animal models. Subsequently, she collaborated with the Royal Marsden Hospital in London to evaluate 4-OHA in breast cancer patients. The researchers found that the aromatase inhibitor not only suppressed serum estrogen concentrations, but also reduced tumors in postmenopausal patients with advanced breast cancer who had relapsed from tamoxifen or other treatments. This first selective aromatase inhibitor came into worldwide use in the early 1990s from Novartis. Dr. Brodie’s pioneering studies paved the way for three other FDA approved aromatase inhibitors.

Dr. Brodie is currently investigating new strategies for treating hormone resistant breast cancer based on understanding the molecular mechanisms involved. Dr. Brodie is also investigating androgen synthesis inhibitors to treat prostate cancer. A novel compound developed by her group has recently started clinical trials.

Gabbay Award

On Monday, Nov 10, Prof. Alfred Goldberg from Harvard Medical School will be on campus to receive the 2008 Jacob Heskel Gabbay Award and to deliver a lecture on the topic “Functions of the proteasome from protein degradation and immune surveillance to cancer therapy”

For more information, see the online exhibit at brandeis.libguides.com

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