Members of the Hedstrom lab have cooked up a new structural model for inosine-5′-monophosphate dehydrogenase (IMPDH), see below:
IMPDH and retinal degeneration
Recent work from the Hedstrom Lab suggests an explanation for how mutations in this enzyme involved in nucleotide biosynthesis can lead to retinal degeneration and hereditary blindness. It seems it has to do with binding mRNA. Read more at: