New structural model for IMPDH

Members of the Hedstrom lab have cooked up a new structural model for inosine-5′-monophosphate dehydrogenase (IMPDH), see below:

Confectioner's model of IMPDH

Edible model of IMPDH

IMPDH and retinal degeneration

Recent work from the Hedstrom Lab suggests an explanation for how mutations in this enzyme involved in nucleotide biosynthesis can lead to retinal degeneration and hereditary blindness. It seems it has to do with binding mRNA. Read more at:

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