William T. Newsome to Receive 2015 Pepose Award on March 18

William NewsomeWilliam T. Newsome, a Stanford neuroscientist, will receive the 6th annual Jay Pepose ’75 Award in Vision Science on March 18. Newsome will deliver a lecture, “A New Look at Gating: Selective Integration of Sensory Signals through Network Dynamics,” on March 18 at 4:00 PM. The lecture will be held in Gerstenzang 121 and is open to the public.

Professor Newsome’s research at Stanford has helped scientists better understand the connection between visual perception and visually guided behavior. Newsome is the Harman Family Provostial Professor at the Stanford School of Medicine and is the Vincent V.C. Woo Director of the Stanford Neuroscience Institute.

The Pepose Award is funded by a $1 million endowment through a gift from Brandeis alumni Jay Pepose ’75, MA’75, P’08, P’17, and his wife,  Susan K. Feigenbaum ’74, P’08, P’17, through the Lifelong Vision Foundation. The endowment also supports graduate research fellowships in vision science.

Learn more

Shantanu Jadhav Wins Sloan Research Fellowship

Shantanu Jadhav

Shantanu Jadhav, assistant professor of Psychology and Neuroscience and one of our newest faculty members, has won the prestigious Sloan Research Fellowship from the Alfred P. Sloan Foundation.

Jadhav’s research focuses on how the hippocamus and the prefrontal cortex interact and communicate with each other.  This activity influences the brain’s ability to learn, remember and make decisions.

More information about Shantanu Jadhav’s research and the Sloan Research Fellowship can be found at Brandeis NOW.

 

 

“Scientist of small things”

IMAGE: BMXIMAGE (from Forbes India)

IMAGE: BMXIMAGE (from Forbes India)

Forbes India recently named Brandeis post-doc alumna Prerna Sharma as one of India’s “30 under 30″. Sharma, who worked in Prof. Zvonimir Dogic’s group in Physics, is currently an Assistant Professor at the Indian Institute of Science (IISc), Bangalore.

Read the original at Prerna Sharma: The scientist of small things, or perhaps her 2014 Nature paper on Hierarchical organization of chiral rafts in colloidal membranes

 

SPROUT grant opportunity for 2015 announced

From the Brandeis Office of Technology Licensing:

The Brandeis Virtual Incubator invites members of the Brandeis Community (faculty, staff and students) to submit an application for the SPROUT Program. These Awards are intended to stimulate entrepreneurship on campus and help researchers launch their ideas and inventions from the lab to the marketplace.The SPROUT Program will provide pilot funding for innovative scientific projects within the Division of Science that require bench research, lab space, and/or lab equipment.

We will be awarding $50,000 to be shared among the most promising proposals.
Come get your questions answered at one of our upcoming information sessions.
Info Sessions: 
Thursday, February 26,  11:00 a.m.-12:00 p.m. (Volen, room 201)
Monday, March 2,  2:00 p.m.-3:00 p.m.   (Shapiro Science Center, 1st Floor Library, room 1-03)
 
Deadlines: Preliminary Proposals are due by Friday, March 6th
Please note, the introduction of the new SPARK Program geared towards innovative non-bench projects that have impact. An additional email will be sent detailing this program.
For more information on each program go to our website or contact the OTL program leaders,  Melissa Blackman for SPROUT and  Anu Ahuja  for SPARK.

Deser to receive 2015 Einstein Medal

From BrandeisNOW:

In May, the Albert Einstein Society will award [Professor Emeritus of Physics Stanley Deser] and University of Maryland colleague Charles Misner the prestigious Einstein Medal for their contributions to the study of General Relativity. The ceremony will take place in Bern, Switzerland, where Einstein began his career.

Sleep and memory are connected by a pair of neurons in Drosophila

In a recent post on the Fly on the Wall blog, Neuroscience grad student Bethany Christmann talks about recently published research from Leslie Griffith’s lab:

 … [How are sleep and behavior] connected in the brain? Does sleep simply permit memory storage to take place, such that the part of the brain involved in memory just takes advantage of sleep whenever it can? Or are sleep and memory physically connected, and the same mechanism in the brain is involved in both? In a recent study published in eLife, researchers in the Griffith lab may have [uncovered the answer]. They found that a single pair of neurons, known as the DPM neurons, are actively involved in both sleep and memory storage in fruit flies.

Haynes PR, Christmann BL, Griffith LC. A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. eLife. 2015;4.

Irving Epstein Interviewed by NPR about Alan Turing

Alan_Turing_photob_0Irving Epstein, Professor of Chemistry, was recently interviewed by NPR about Alan Turing and a paper (Testing Turing’s theory of morphogenesis in chemical cells) that he co-authored with Nathan Tompkins, Ning Li, Camille Girabawe, Michael Heymann, Seth Fraden and G. Bard Ermentrout earlier this year. The paper discussed an experiment that they performed that confirmed and improved upon Alan Turing’s theory about morphogenesis.

Alan Turing is credited with inventing the modern computer and breaking the German Enigma code during World War II. That work is spotlighted in the upcoming movie titled “The Imitation Game”. After World War II, Turing turned his focus to biology. He investigated how a single embryonic cell develops into a complex organism with hundreds of different kinds of cells. He wrote The Chemical Basis of Morphogenesis in 1952.

Listen to the interview …

Mitosis: One Polo controls it all

On November 6, 2014, Cell Cycle published a paper from the Yoshida lab entitled “The budding yeast Polo-like kinase Cdc5 is released from the nucleus in anaphase for timely mitotic exit.” This study was authored by Vladimir V. Botchkarev Jr., Valentina Rossio, and Satoshi Yoshida.

The cell cycle is one of the most fundamental biological processes whose ultimate goal is cell division with equal content of DNA in both daughter cells. The process of cell division is regulated by many intracellular events which must occur in a sequential order. These events include mitotic entry, faithful chromosome segregation, mitotic exit, and cytokinesis. Over the past 25 years, the Polo-like kinase (Polo) has been established to play important regulatory roles in each of these processes. Although many mitotic substrates of Polo have been discovered, the mechanism by which Polo can coordinate all of these mitotic events has remained largely elusive.

To understand the mechanism by which Polo can target its many substrates in a sequential order during mitosis, we decided to study the budding yeast Polo kinase Cdc5, which has high conservation with the human Polo-like kinase 1.

We found that Cdc5-GFP dynamically changes its localization during the cell cycle: Cdc5 is found in the cytoplasm in S- through early G2-phase, it accumulates in the nucleus at metaphase, and is released again to the cytoplasm in anaphase. Blocking nuclear import of Cdc5 in metaphase leads to a prolonged metaphase duration, suggesting that nuclear Cdc5 is required for chromosome segregation. In contrast, blocking nuclear release of Cdc5 in anaphase results in a prolonged anaphase duration, a defect in activation of the cytoplasmic Mitotic Exit Network, and a defect in cytokinesis. This indicates that Cdc5 is released from the nucleus to the cytoplasm in anaphase for timely mitotic exit and cytokinesis. We further found that activation of the Cdc14 phosphatase, a known nuclear substrate of Cdc5, is required for Cdc5 nuclear release in anaphase.

Collectively, our work reveals that the budding yeast Polo-like kinase Cdc5 controls the timing of mitotic events by dynamically changing its sub-cellular localization. Furthermore, our data suggests the existence of a positive feedback look between Cdc5 and Cdc14 to regulate timely mitotic exit. Read more

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