Money for summer research projects and fellowships

Joan Press, Undergraduate Advising Head for Biology, wrote:

Over the next few weeks Academic Services will be holding several Info Sessions about the Summer URP and Jerome A. Schiff Fellowships, both of which fund undergraduate research projects.  The Summer URP allows students to ask for any amount from $50-$2,000 to fund summer research, whereas the Schiff’s funding (~$2,000) is designed for larger, (school)year-long projects.  The deadlines will be in mid-March and First-years, Sophomores and Juniors from all departments are all encouraged to apply.

  • Thursday, February 4, 4pm, Academic Services Conference Room (2nd Floor, Usdan)
  • Tuesday, February 9, 3pm, Academic Services Conference Room (2nd Floor, Usdan)
  • Wednesday, February 10, 12pm, Academic Services Conference Room (2nd Floor, Usdan)
  • Monday, February 22, 12pm, Academic Services Conference Room (2nd Floor, Usdan)

Undergraduate authors

Brandeis is proud of its tradition of undergraduates working in science labs,  alongside grad students, staff and postdocs. This work often leads to publications in the primary scientific literature (see list of undergraduate publications).

The most recent of these, by Nicholas Hornstein and collaborators in the Griffith lab, appears in the Journal of Visualized Experiments. This new journal focuses on using streaming video to provide access to high quality demonstrations of lab procedures (in this case, demonstrating dissection technique for doing neurophysiology in Drosophila larvae).

Drosha and Pasha

No, this isn’t a Russian short story.

Lead authors postdoc alum Sebastian Kadener and Mol Cell Biol graduate student Joe Rodriguez and their coworkers used tiling arrays to look for targets of the enzyme Drosha in “Genome-wide identification of targets of the drosha–pasha/DGCR8 complex”, a paper recently published in the journal RNA. Drosha is a type III RNAse that is involved in the processing of  miRNAs. This paper demonstrates for first time that this enzyme is not only involved in miRNA processing, but can also process mRNAs.  Interestingly, the best example of an mRNA processed by Drosha is the mRNA that encodes another miRNA processing enzyme, the protein Pasha. As this is a partner of Drosha (the two proteins work together), the findings suggest that  there is a feedback loop that controls the abundance of the miRNA processing machinery and probably the abundance of miRNAs themselves.

Chloride channels and antiport mechanism

In a new paper in Journal of General Physiology, Brandeis postdoc Hyun-Ho Lim and Professor Christopher Miller examine the detailed mechanism by which a chloride transporter protein works. In particular, this protein does a rather crazy thing: it stoichiometrically swaps a proton on one side of the membrane for two Cl- ions on the other, and countertransports them across the membrane.  In this work, the authors identify a special glutamate residue on the cytoplasmic side of the protein that is responsible for picking up protons on that side in order to carry out this “antiport” mechanism.  (That glutamate is indicated by the spacefilled residue with red oxygen atoms in this depiction of the dimeric protein.)

Is my DNA fixed yet?

A broken chromosome (a double-strand DNA break) activates the DNA damage checkpoint to prevent cells from carrying out mitosis until the break has been repaired.  Repair of the break involves the modification and the removal of histone protein octamers from DNA around the break and these must be reestablished when repair is complete.  In a new paper in PNAS, Brandeis alumnus Jung-Ae Kim (Ph.D., Molecular and Cell Biology, 2008) and Professor James Haber show that when two of the major histone chaperone protein complexes (Asf1 and CAF-1) are deleted in yeast cells, their absence prevents cells from turning off the DNA damage checkpoint and hence cells stay permanently arrested.   These results suggest that cells specifically monitor the re-establishment of normal chromatin status after DNA repair.

Recent Grant Awards

Neuroscience Ph.D. candidate Melanie Gainey received an NRSA Fellowship from NINDS. Working in the Turrigiano lab, Melanie plans to study the role of the AMPA receptor subunit GluR2 in synaptic scaling in cultural neurons and in vivo using a conditional GluR2 knockout mouse.

Assistant Professor Suzanne Paradis received a Smith Family New Investigator Award from the Richard & Susan Smith Family Foundation. $300,000 in support over three years will support the lab’s efforts to study synapse development and specifically the role of the Sema4B protein in controlling synapse formation.

Professor Leslie Griffith received $1.1 million over 5 years from NIMH to study why sleep is required for effective memory formation. To understand this linkage at a cellular and molecular level, the Griffith lab is defining the circuits that regulate sleep in Drosophila and how these circuits affect memory formation.

Professor Larry Wangh received $1.38 million over the next year from Smiths Detection to continue research and invention of LATE-PCR et al., platform technologies for highly informative detection and diagnosis of nucleic acids in a single tube.  There are ongoing projects looking at applications to cancer, prenatal genetics, and several infectious diseases in people and animals.

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