On April 24, a Children’s Leukemia Research Association (CLRA) award was presented to Jerry Brown, a Senior Research Scientist who works with Carolyn Cohen at the Rosenstiel Basic Medical Sciences Research Center. The award will help fund research on structures of α-helical coiled-coils, in particular those from myosin implicated in certain leukemias. The α-helical coiled coil is a common dimerization motif in proteins and is implicated in many normal physiological as well as pathological processes. Many cases of acute myeloid leukemia involve the aberrant fusion of the transcription factor, CBFβ, to a long portion of the smooth muscle myosin rod, which is predicted from its amino acid sequence to form an α-helical coiled coil. A major aim of the proposed research is thus to crystallize and determine the atomic structures of the segment of the myosin rod nearest this fusion point, both in its normal unfused physiological state and when aberrantly fused to CBFβ. A related aim of the research is to understand how the conformations of α-helical coiled coils in general are affected by attached structures. Accomplishment of these aims may provide a structural basis for the rational design of drugs that can selectively disrupt the activity of the pathologically fused protein.
In addition to Dr. Brown and Professor Cohen, the award presentation was attended by their laboratory researchers Senthil Kumar, Ludmila Reshetnikova, and Elizabeth O’Neall-Hennessey, Rosenstiel Director James Haber, Brandeis Office of Research Administration Associate Director Patricia McDonough, Rosenstiel Department Operations Manager Anahid Keshgerian, CLRA President Anthony Pasqua, his daughter Susan (Pasqua) Bogue, a survivor of leukemia, and Nancy Golden and three of her children. The award is named after another daughter of Nancy Golden, Amy Golden Uleis, who lost her battle with cancer at age 52 and was a graduate of Brandeis. The award presentation was accompanied by a photo-op and a small reception held at Rosenstiel.