SciFest VIII wrap-up

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The Brandeis University Division of Science held its annual undergraduate research poster session SciFest VIII on August 2, 2018, as more than one hundred student researchers presented summer’s (or last year’s) worth of independent research. We had a great audience of grad students and postdocs (many of whom were mentors), faculty, proud parents, friends, and senior administrators.

SciFest VIII by numbers

  • 105 posters
  • 105 student presenters out of approx. 175 summer student researchers
    • 84 Brandeis students
    • 2 international students (from India)
    • 19 visiting domestic students
  • 41 Brandeis faculty advisors from 7 departments
    • Biochemistry (7)
    • Biology (17)
    • Chemistry (5)
    • Computer Science (1)
    • Mathematics (1)
    • Physics (7)
    • Psychology (4)
  • 12 different Brandeis undergraduate majors represented

SciFest VIII will be on Thursday, Aug 2

Scifest VIII, our annual Poster Session featuring undergraduate researchers, will be held on Thursday, August 2. The poster session will be 1:00 to 3:00 pm in the Shapiro Science Center atrium.

SciFest features undergrads who have spent their summers working in both on-campus and off-campus labs doing scientific research, usually alongside grad students, postdocs and faculty members. It an opportunity for these dedicated students from across the Division of Science, including summer visitors and Brandeis students, to present their research for peers and the community.

As of today, 107 students have registered to present.

The public is invited to attend and to discuss research with the students. As always, refreshments will be served.

Brandeis receives $1 million HHMI Inclusive Excellence Initiative grant

HHMI logoBrandeis is one of 57 schools to receive a $1 million 5-year grant from the Howard Hughes Medical Institute’s (HHMI’s) Inclusive Excellence Initiative, the aim of which is “to create a community of scientists and science educators engaged in 57 experiments, each experiment aimed at understanding how institutional change with respect to inclusion can be achieved.” Under the direction of Henry F. Fischbach Professor of Chemistry and HHMI Professor Irving Epstein, Professor of Biology Melissa Kosinski-Collins and Associate Provost Kim Godsoe, the program has four major thrusts: a) Galaxy, a cohort based program, modeled on Brandeis’s highly successful Science Posse, to provide peer and near-peer support and mentorship for prospective science majors; b) workshops, incorporated into introductory laboratory courses, that address issues such as imposter syndrome, implicit bias and stereotype threat and encourage students to reflect upon the learning environment that they wish to create for themselves and their classmates; c) low-enrollment practicum courses designed to strengthen students’ quantitative skills through project-based research studies; and d) a faculty learning community that will bring together instructors in key courses to grapple with issues that may hamper student performance and retention.  The discussions in b) and d) will be informed by written and oral presentations from students and alumni, who will be asked to reflect on how their preparation and their reception by faculty and other students affected their experience in STEM.  These initiatives will help Brandeis change the culture and climate of how the community perceives all students studying STEM.

A major impetus for this undertaking is the recognition that students in the sciences begin with a wide range of preparation and experience, and that currently retention in science majors is heavily correlated with level of preparation and initial success in introductory courses.  Nationally, only 48% if students entering college with the intention of majoring in STEM (science, technology, engineering and mathematics) actually complete a STEM major.  At Brandeis the record is somewhat better, but there is still much room for improvement.  The programs in this initiative are designed to overcome the “sink or swim” mentality that affects many students (and faculty) by making them aware that, with appropriate support and perseverance, all students can succeed in the sciences no matter where they start from, even if the road is rocky at the start.

2018 Prizes and Awards Announced

Congratulations to all recipients of the 2018 prizes and awards for the Division of Science and the departments and programs within the Division.

Division of Science Prizes and Awards

  • Doris Brewer Cohen Award: Richard Haburcak (Math, Chemistry)
  • Rishon M. BIaler ’64 Memorial Prize: Abraham Cheloff (Biology, Neuroscience, Chemistry)
  • Schiff Memorial Award in Science: Meisui Liu (Biology) and Kathryn Shangraw (Biology)
  • Division of Science Prize for Outstanding Research Accomplishment: Heather Schiller (Biology, Neuroscience) and Jordan Saadon (Biology, Neuroscience)
  • Dr. Ralph Berenberg ’65 Prize (dentistry): Brandon Tran
  • Elihu A. Silver Prize (junior research): Julia Tartaglia (Biochemistry)
  • Steinberg Prize (Physical Science with interest in History): Mihir Khanna (Physics, Art History minor)

Biochemistry Prizes and Awards

  • Nathan O. Kaplan Prize in Biochemistry: Jessie Moore (Senior)
  • Professor Dagmar Ringe Biochemistry Award: Miriam Hood (Senior)
  • William P. Jencks Award in Biochemistry: Senmiao Sun (Senior)

Biology Prizes and Awards

  • Biology Department Award For Excellence in Research: Jason Xin
  • Chandler Fulton Prize for Undergraduate Research: Theresa Weis

Chemistry Prizes and Awards

  • Anatol Zhabotinsky Memorial Prize: Sumner Alperin-Lea
  • American Chemical Society Division of Physical Chemistry 2018 Undergraduate Award: Sumner Alperin-Lea
  • Chemistry Department Excellence Award: Samantha Shepherd
  • Melvin M. Snider Prize in Chemistry: Jamie Soohoo
  • American Chemical Society Division of Inorganic Chemistry 2018 Undergraduate Award: Elishua D. Litle
  • American Chemical Society Division of Organic Chemistry 2018 Undergraduate Award: Elishua D. Litle
  • Emily Dudek Undergraduate Teaching Assistant Award: Miriam Hood; Steven Wilhelm

Mathematics Prizes and Awards

  • Jerome Levine Thesis Prize (given annually to a graduate student in mathematics finishing with an outstanding PhD thesis): Yan Zhuang
  • Arnold Shapiro Prize in Mathematics (to a senior who has shown unusual talent and accomplishments in mathematical studies): Richard Haburcak

Neuroscience Prizes and Awards

  • Reis and Sowul Family Prize in Neuroscience: Amanda Shilton
  • John Lisman ’66 Memorial Award for Excellence in Neuroscience Research: Megan Leubner and Casey Lamar

Physics Prizes and Awards

  • Stephan Berko Memorial Prize (This endowed prize was established in 1991 by the family of the late Dr. Berko to annually recognize an outstanding student in Physics): Ali Aghvami (graduate); Carl Merrigan (graduate); Zachary Sustiel (undergraduate)
  • David L. Falkoff Prize (The Falkoff  Prize annually recognizes a graduate student in Physics who demonstrates excellence in teaching): Daichi Hayakawa
  • Physics Faculty Prize (Awarded to a graduating senior for excellence in Physics): Guillermo Narvaez Paliza; Liana Simpson

 

 

Grant funding for undergraduates doing Computational Neuroscience

The Division of Science is pleased once again to announce the availability of Traineeships for Undergraduates in Computational Neuroscience through a grant from the National Institute on Drug Abuse. Traineeships will commence in summer 2018 and run through the academic year 2018-19.

Please apply to the program by March 1, 2018 at 6 pm to be considered.

Computational Neuroscience undergraduate trainees were first authors on 2 papers in 2017; figure above from Christie et al., J. Neurophysiol., 2017

Traineeships in Computational Neuroscience are intended to provide intensive undergraduate training in computational neuroscience for students interested in eventually pursuing graduate research. The traineeships will provide approximately $5000 in stipend to support research in the summer, and $3000 each for fall and spring semesters during the academic year. Current Brandeis sophomores and juniors (classes of ’19, ’20) may apply. To be eligible to compete for this program, you must

  • have a GPA > 3.0 in Div. of Science courses
  • have a commitment from a professor to advise you on a research project related to computational neuroscience
  • have a course work plan to complete requirements for a major in the Division of Science
  • complete some additional requirements
  • intend to apply to grad school in a related field.

Interested students should apply online (Brandeis login required). Questions that are not answered in the online FAQ may be addressed to Steven Karel <divsci at brandeis.edu> or to Prof. Paul Miller.

Rodal lab find surprising new link between inflammation and Lowe Syndrome

Could a disease with symptoms in the brain, eyes, and kidneys actually be caused by problems with immune cells? A team of scientists from the Rodal Lab, co-first authored by Steven Del Signore and Sarah Biber and including three Brandeis undergraduates (Katy Lehmann ‘16, Stephanie Heimler ‘17, and Ben Rosenfeld ’18), think this just might be the case with Lowe Syndrome, in a new paper published Oct 13th in PLOS Genetics.

Patients with Lowe Syndrome suffer from kidney failure, congenital cataracts, and several neurological problems including intellectual disability and seizures. Scientists have known for some time that the disease is caused by mutations in a gene called OCRL, but remain unsure how its loss causes such a diverse array of symptoms. A big problem has been that OCRL appears to do many different jobs inside cells, including controlling how they divide, how they sense their surroundings, and how they store and transport materials inside small packages called endosomes.

Fly immune cells showing the tracks of moving endosomes. Single tracks represent the path of individual endosomes over time.

To try to solve this mystery, a team of researchers from the Rodal lab used the fruit fly, which has its own version of the OCRL gene and allowed the investigators to perform powerful genetic experiments to figure out precisely what OCRL is doing, and where. To do this, the group created a fly missing its OCRL gene. They were surprised to find that, rather than eye or neurological defects, loss of OCRL hyper-activated cells of the innate immune system. The innate immune system is the first line of defense against infection in humans (and the only defense in fruit flies), when cells release inflammatory signals that mobilize specialized cells to attack invading pathogens.

The team determined that OCRL is required in one of these specialized immune cells in the fly, and that the immune-cell activation was caused by problems in a particular step of intracellular transport. Every cell of the body has its own postal service, which is used to pack and ship signals that tell the cell or its neighbors to grow, divide, or jump into action (see movie here to watch endosomes moving inside living fly immune cells). The OCRL mutant immune cells had a problem in a key step that controls whether signals get thrown in the trash or shipped outside the cell, and this caused the immune activation.

How do these findings relate to Lowe Syndrome? The authors think these results suggest a possible cause for the seizures that patients experience. When similar immune-like cells in the brain release excessive inflammatory signals, it can cause several forms of epilepsy. Further, OCRL has been linked to at least one mouse model of epilepsy. Going forward, the researchers will try to identify which immune signals are responsible, and how these findings translate to human cells.

Del Signore SJ (*), Biber SA (*), Lehmann KS, Heimler SR, Rosenfeld BH, Eskin TL, Sweeney ST, Rodal AA. dOCRL maintains immune cell quiescence by regulating endosomal traffic. Plos Genet. 2017;13(10):e1007052.

 

 

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