SPOTLIGHT ON JOBS
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Where: Zhao Research Laboratory at the Hospital for Special Surgery and Weill Cornell Medical College in New York, NY
The Zhao Lab is particularly interested in the key inflammatory cytokine TNF-mediated osteoclastogenesis and bone resorption. By comparing with the physiological osteoclastogenic inducer RANKL, the lab has aimed to distinguish and identify novel regulators, for example IRF-8 and RBP-J, that predominantly control pathological bone resorption, thereby providing specific therapeutic targets for clinic with minimal side effects on physiological bone remodeling. The lab employs a combination of molecular and cellular approaches as well as various mouse models, including the inflammatory arthritis model and osteoporosis model for our research. Besides the coding genes, the lab recently challenged a new field- genome wide study of non-coding RNAs (ncRNAs). By using modern genomic approaches including second-generation deep sequencing and bioinformatics analysis they have successfully identified a few promising novel ncRNAs that were unable to reveal by traditional methods. The lab has opened a pioneering research area studying non-coding genes in osteoclast biology and osteolysis.
Seeking a laboratory technician who is interested in and has expertise in epigenetic and genome-wide studies. The lab uses bone marrow macrophages as osteoclast precursors and study the role of TNF and Notch/RBP-J signaling in their differentiation process. Competitive salary and an excellent benefits package (Medical, Dental, Life insurances and housing supplement) are available and will commensurate with experience and accomplishments.
- Recent master’s in bioinformatics, biostatistics, or a related field
- A record of peer reviewed publications
- Have expertise in the analysis of ChIP-seq or RNA-seq , clustering, and pathway enrichment
- Knowledge of R, Python, or Perl
- Familiarity with molecular biology is preferred
- High level of motivation and the ability to think critically
Please make sure to reference seeing this position through the Brandeis GPS job spotlight post.
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