The Rogers Lab receives a prestigious international grant to study the origin of life

HFSP logoProfessor W. Benjamin Rogers in the Department of Physics has been awarded a 2020 Human Frontier Science Program (HFSP) collaborative Program Grant to create a self-propagating synthetic cell. The HFSP Program Grants aim to tackle big questions in the life sciences by supporting and bringing together researchers with different backgrounds from different countries. Professor Rogers’ team grant was one of 20 successful Program Grants that went through a year-long global selection process.

The project aims to build a stably-propagating cell from simple components. The cell will have a lipid membrane encapsulating DNA and transcription-translation machinery, and be able to grow and divide by internally synthesizing its own membrane material.

The project is significant because a stably propagating cell is a vital element of natural selection. Extant life on Earth is a consequence of natural selection acting upon earlier forms of life, shaping the lineages over time. Thus at some point early in life’s origins, a sustainably propagating cell must have emerged, allowing selective advantages to accumulate over successive generations. For daughter cells to have retained the attributes of their parent, both the genetic information and the cell contents must have been replicated with reasonable fidelity.  However, it is currently unclear how controlled cell division could have first emerged from relatively simple molecules. It is precisely this mystery that the team hopes to understand by attempting to recreate it in a test tube.

Professor Rogers’ grant is shared with Dr. Yutetsu Kuruma from Japan Agency for Marine-Earth Science and Technology and Professor Anna Wang from University of New South Wales in Australia.

Even Dankowicz is named 2019 Goldwater Scholar

Even Dankowicz, fly image

photo: Even Dankowicz

Even Dankowicz, a rising senior majoring in Biology, has been named a 2019 Goldwater Scholar. The Goldwater Scholarship is a national scholarship designed to encourage outstanding students in their sophomore and junior year to pursue research careers in the fields of mathematics, the natural sciences, and engineering.

He has always been particularly interested in animals (including insects), but it was a high school biology teacher that inspired Even to think more seriously about working with insects. “Insects and other arthropods seemed especially worth studying because they are disproportionately diverse and abundant, making up ~95% of the species I found in my yard. Up close, they are also often exceptionally beautiful.” The image above is one of his favorites – it is a wasp-like flower fly from his yard in Illinois.

After his freshman year at Brandeis, Even spent the summer at the Smithsonian revising the taxonomy of a tropical Asian Mydas-fly genus, discovering six new species. Last summer he worked at Harvard on a gene-sequence-based evolutionary tree of a tropical Asian butterfly genus. He has continued to be involved with both of these projects/research groups, and is currently back at the Smithsonian looking at the comparative morphology of fly pupae.

Along with Colleen Hitchcock, Assistant Professor of Ecology, Even worked on local biodiversity-focused citizen science, which has shown him the potential value of this data and motivated him to curate insect observations on iNaturalist and BugGuide, two citizen science websites. Even (with Chris Cohen from East Carolina University) recently contributed an article to Fly Times titled “Diptera and iNaturalist: A case study from Asiloidea”. The article provides a detailed description of iNaturalist. Dankowicz and Cohen used this platform extensively for their studies in Diptera.

In the future, Even says that he thinks he’d like to keep working with insects, “either to understand their evolution or another aspect of their biology.” This spring, Even took an class on evolutionary developmental biology (evo-devo) with Assistant Professor Maria de Boef Miara, which has been useful in his current project at the Smithsonian. Additionally, he is starting to work on applications for graduate school next year.

Sadelin & Campana Receive 2019 Gabbay Award on October 2

2019 Gabbay Award winners

Michel Sadelain, the director of the Center for Cell Engineering at the Memorial Sloan Kettering Cancer Center (MSKCC), and Dario Campana, a professor of pediatrics at the Yong Loo Lin School of Medicine at the National University of Singapore (NUS) will receive the 2019 Jacob and Louise Gabbay Award in Biotechnology and Medicine on Wednesday, October 2, 2019 at 4:00 PM at Shapiro Campus Center Theater. Michel Sadelin and Dario Campana will deliver a talk at that time.

Both scientists receive the Gabbay Award this year for their research into CAR T-cell therapy that has resulted in breakthrough cancer treatments.

The Gabbay Award was created in 1998 by the Jacob and Louise Gabbay Foundation in order to recognize scientists working in academia, medicine or industry for their outstanding achievements developing scientific content and significant results in the biomedical sciences.

Read more at BrandeisNow.

Eve Marder and Irving Epstein named University Professors

 

Eve Marder & Irving Epstein

Congratulations to Eve Marder, Victor and Gwendolyn Beinfield Professor of Neuroscience and Irving Epstein, Henry F. Fischbach Professor of Chemistry, for being named University Professors. This is one of the most prestigious academic honors at Brandeis University. This honor is bestowed on faculty members whose renown crosses disciplinary boundaries; who have achieved exceptional scholarly or professional distinction within the academic community; and whose appointment will enhance the university’s reputation. Read more at BrandeisNow

A celebration Eve, Irving and the 25th anniversary of the Volen Center will be held on November 17, 2019.

Jeff Gelles elected to American Academy of Arts and Sciences

Jeff Gelles, 2019 AAAS recipient

credit: Heratch Ekmekjian

Jeff Gelles, the Aron and Imre Tauber Professor of Biochemistry and Molecular Pharmacology, has been elected to the American Academy of Arts and Sciences. He was among the  more than 200 outstanding individuals that were elected to the Academy in 2019 and announced on April 17.

The Gelles lab studies “little engines” or the nanometer-sized machines made of protein, RNA, and DNA molecules that carry out the essential processes in living cells.  The lab uses single-molecule light microscopy methods to study the functional mechanisms of these macromolecular complexes in cytoskeletal function, transcription and transcription regulation, and RNA processing.

Founded in 17890, the Academy recognizes the outstanding achievements of individuals in academia, the arts, business, government, and public affairs.

Read more: Amacad.org, BrandeisNow

 

 

 

 

Cepko to present Lisman Memorial Lecture April 9, 2019

Constance CepkoFor the 11th year, a top neuroscientist specializing in vision will present an awarded lecture to the Brandeis community. This year’s awardee is Dr. Connie Cepko of Harvard Medical School and the Howard Hughes Medical Institute, an expert in retinal development and molecular tool design. Connie will present a lecture entitled “Development of the Vertebrate Retina and Nanobodies as Regulators of Intracellular Activities” at 12:30pm in Gerstenzang 121.

The Lisman Memorial Lecture honors the memory of John E. Lisman (’66), who was a faculty member in Biology from 1973 until his death in 2017. The award is endowed through the generous contribution of Brandeis alumni Jay Pepose ’75, MA’75, P’08, P’17, and his wife, Susan K. Feigenbaum ’74, P’08, P’17. (Alumni.brandeis.edu)

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