Griffith lab finds that time-keeping brain protein influences memory

Figure from Griffith lab paperIn the Journal of Neuroscience, members of the Griffith Lab found that memory impairments can result from disruptions in the release of the peptide Pigment-dispersing factor (PDF). PDF aligns the brain’s time-keeping mechanism to the correct time of day.

Upsetting the brain’s timekeeping can cause cognitive impairments, like when jetlag makes you feel foggy and forgetful. These impairments may stem from disrupting a protein that aligns the brain’s time-keeping mechanism to the correct time of day, according to new research in fruit flies published in JNeurosci.

The brain contains ‘clock’ neurons that collectively mold circadian behaviors and link them to cues from the environment, like light and seasonal changes. In fruit flies, the peptide Pigment-dispersing factor (PDF) is released from the clock to both synchronize the activity of the clock neurons and to drive time-based behaviors like mating and sleep. PDF may also underlie memory formation, explaining the cognitive dysfunction that occurs when the clock is desynchronized from the environment.

Flyer-Adams et al. tested how well fruit flies with a functioning core clock, but lacking the PDF output signal, could learn. They found that without PDF signaling, flies had severely impaired memory. Interestingly, memory regulation by PDF likely occurs without direct signaling to the main memory structure of flies. Their results suggest that PDF from the clock may promote normal memory throughout the day by acting as a timestamp to learning. The VIP pathway in humans may play a similar role.

Publication:

Regulation of olfactory associative memory by the circadian clock output signal Pigment-dispersing factor (PDF). Johanna G. Flyer-AdamsEmmanuel J. Rivera-RodriguezJunwei YuJacob D. MardovinMartha L. Reed and Leslie C. Griffith. 

Former Marder Student Receives Prestigious Award

Vatsala Thirumalai

Photo: NCBS

A former graduate student from Eve Marder’s lab has received the prestigious Shanti Swarup Bhatnagar Prize for 2020.  Vatsala Thirumalai was a graduate student in the Marder lab from 1996 to 2002. She received her PhD in Neuroscience from Brandeis University in 2002.

Thirumalai was one of twelve researchers to receive India’s highest science award. She is a faculty member in the Biochemistry, Biophysics and Bioinformatics department at the National Centre for Biological Sciences in Bangalore, India. Her lab is focused on neural circuits that control movement during development and adulthood in animals.

The Shanti Swarup Bhatnagar Prize is awarded by the Council of Scientific and Industrial Research (CSIR) to Indian scientists below the age of 45 for outstanding research in seven fields—Biology, Chemistry, Environment Science, Engineering, Mathematics, Medicine and Physics.

After receiving her degree from Brandeis, Vatsala did post-doctoral fellowships in Neuroscience at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY and the National Institutes of Health, Bethesda, MD.

More info: CSIR Announces Awardees of Shanti Swarup Bhatnagar Prize for 2020Shanti Swarup Bhatnagar Prize 2020: 12 researchers receive India’s highest science award.

Meet the Science UDRs at the Ultimate Science Navigation Event (9/23)

Ultimate Science Navigation posterAt The Ultimate Science Navigation event TOMORROW (9/23), students can collaborate with the science UDRs to learn about the different offerings in the sciences, how to navigate each major/minor, what each major/minor has to offer, all with an emphasis on exploring the intersections between different programs in the sciences. We will have UDRs representing biochemistry, biology, neuroscience, chemistry, physics, and biophysics!

Students can join in the morning on Zoom from 9:30-10AM, or for the rest of the day through the new Brandeis science community Slack workspace to discuss their questions related to the majors with the UDRs! Email Lance Babcock (lbabcock@brandeis.edu), Maggie Wang (maki@brandeis.edu) or the other science UDRs for the Zoom link and Slack workspace link.

Working towards diversity, equity and inclusion in the sciences

Bulbul ChakrabortyBulbul Chakraborty
Enid and Nate Ancell Professor of Physics
Division Head, Sciences, School of Arts and Sciences

This blog is addressed to my colleagues in the division of science. 

As scientists, we pride ourselves on solving problems, often ones that lead to paradigm shifts.  A challenge that we have all grappled with is how to cultivate and nurture a truly diverse community of scientists.  How do we create an environment that is inclusive and accessible to all that seek to enter the sciences and experience the invigorating practice of  science that  we live and breathe?  How do we open our doors and not be gatekeepers? 

I am writing this blog because the many conversations that I have had over this summer has convinced me that this is the right time for a concerted effort to push towards our objectives. As scientists we know that half the battle is going to the core of a problem, and representing it in a way that tells us what actions to take.   What I have become aware of is  that the anecdotal evidence on who leaves the sciences is being made quantitative and rigorous.  Words are being put to our experiences and structures are being offered that we can use to take actions.  We have colleagues at Brandeis and in the broader community of science educators that have thought long and hard about how to bring about change in STEM education. We can all learn from them.  

I am urging all of you to share resources that you are aware of that will help us create actionable goals and structural changes.  Towards that, here is a link to an organization called “SEA CHANGE”, within the auspices of the American Association for the Advancement of Science: https://seachange.aaas.org/.  In particular, they are hosting a series of Webinars under the banner “Talking about Leaving Revisited”: https://seachange.aaas.org/events  that I have registered for and I encourage you to do so if you can.

I intend to make this a monthly blog that reflects my thoughts on diversity, equity and inclusion in the sciences at Brandeis.

Applied Mathematics and AI meet Law and Social Justice

Jonathan Touboul

For the past two years, Applied Mathematics Professor Jonathan Touboul and his team has been working in collaboration with Law Professor Samuel Dahan at Queen’s University (Canada) in modeling legal decisions and predicting court decisions on Canadian labor law. Their academic work covers the determination of a worker’s status or the calculation of a severance package (paper appearing in a forthcoming issue of the McGill Law Journal). With the COVID-19 crisis and nearly 2 million Canadian jobs lost in 2 months, Touboul, Dahan, Prof. Maxime Cohen (McGill) and their colleagues realized that their research could be applied to assist more people, and serve to help democratize legal services, particularly towards those who lack proper access to law and legal information.

Joining their efforts with a team of law and computer science students at Queen’s University, Jonathan Touboul and his team provided modeling and data science expertise to develop predictive algorithms that helped launch MyOpenCourt.org. This is a free AI powered platform that offers easy access to their research and algorithms to provide personalized predictions, explanations, list of most similar situations from the case law, and offers the option to connect the user with a network of pro-bono lawyers for a free consultation.

Learn more:

• “Championing AI for social justice”, Queens University
• “Conflict Analytics Lab launches app for workers laid off during the pandemic”, McGill University

SPROUT and I-Corps Applications are Open

Sprout logoThe Brandeis Innovation SPROUT and I-Corps programs offer support for bench and non-bench research. Both programs offer funding in different amounts, mentorship, training and help in further exploring the commercial potential of inventions. SPROUT supports bench research, while I-Corps emphasizes training for both bench and non-bench researchers in developing the commercial potential of discoveries, with small grants and extensive training programs. You can apply to one or both programs.

  • If you have a technology / solution that you have started developing and you would like to get funding for it via SPROUT and/or I-Corps, then please complete this form
  • If you do not already have a technology, then you can complete this form to qualify for the I-Corps training program and be matched with a team

Icorps logo

SPROUT teams will get the chance to qualify for up to $30,000 in funding. The I-Corps program provides entrepreneurial training and covers the core of commercializing a technology or building a startup. It comes with an NSF $750 travel and training stipend and an NSF I-Corps certificate/digital badge.

Apply by February 25, 2020 at 11:59PM

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